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ITGA5 antibody

ITGA5 Reactivity: Human WB, FACS, ELISA, IHC Host: Mouse Monoclonal 10F6 unconjugated
Catalog No. ABIN969221
  • Target See all ITGA5 Antibodies
    ITGA5 (Integrin, alpha 5 (ITGA5))
    Reactivity
    • 102
    • 61
    • 18
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 86
    • 17
    • 8
    • 1
    • 1
    Mouse
    Clonality
    • 76
    • 38
    Monoclonal
    Conjugate
    • 56
    • 11
    • 11
    • 8
    • 7
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This ITGA5 antibody is un-conjugated
    Application
    • 82
    • 49
    • 38
    • 34
    • 15
    • 14
    • 13
    • 12
    • 10
    • 9
    • 8
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunohistochemistry (IHC)
    Purification
    purified
    Immunogen
    Purified recombinant fragment of human ITGA5 expressed in E. coli.
    Clone
    10F6
    Isotype
    IgG2a
    Top Product
    Discover our top product ITGA5 Primary Antibody
  • Application Notes
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, FCM: 1:200 - 1:400
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    4°C, -20°C for long term storage
  • Mould, Askari, Barton, Kline, McEwan, Craig, Humphries: "Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain." in: The Journal of biological chemistry, Vol. 277, Issue 22, pp. 19800-5, (2002) (PubMed).

    Zhao, Newman: "Integrin activation by regulated dimerization and oligomerization of platelet endothelial cell adhesion molecule (PECAM)-1 from within the cell." in: The Journal of cell biology, Vol. 152, Issue 1, pp. 65-73, (2001) (PubMed).

    Wong, Wiedle, Ballestrem, Wehrle-Haller, Etteldorf, Bruckner, Engelhardt, Gisler, Imhof: "PECAM-1/CD31 trans-homophilic binding at the intercellular junctions is independent of its cytoplasmic domain; evidence for heterophilic interaction with integrin alphavbeta3 in Cis." in: Molecular biology of the cell, Vol. 11, Issue 9, pp. 3109-21, (2000) (PubMed).

  • Target
    ITGA5 (Integrin, alpha 5 (ITGA5))
    Alternative Name
    ITGA5 (ITGA5 Products)
    Synonyms
    ITGA5 antibody, Cd49e antibody, Fnra antibody, VLA5 antibody, CD49e antibody, FNRA antibody, VLA5A antibody, Itga5_retired antibody, integrin subunit alpha 5 antibody, integrin alpha 5 (fibronectin receptor alpha) antibody, ITGA5 antibody, Itga5 antibody
    Background

    Description: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. Integrin alpha 5 is a heterodimer that associates noncovalently with CD29/integrin beta 1 subunit to form the alpha-5-beta-1 very late antigen (VLA-5) complex. VLA-5 is a fibronectin receptor that is expressed on thymocytes, T-cells, monocytes and platelets. It is also found on very early B-cells and activated B-cells. VLA-5-mediated binding to fibronectin sends a costimulatory signal to T-cells and enhances Fc-gamma-R- and complement receptor-mediated phago-cytosis. It is also involved in monocyte migration into extracellular tissues.

    Aliases: FNRA, CD49e, VLA5A, ITGA5

    Molecular Weight
    114 kDa
    Gene ID
    3678
    HGNC
    3678
    Pathways
    Integrin Complex
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