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BCMA Protein (AA 2-54, Extracellular Domain) (Fc Tag)

TNFRSF17 Origin: Human, Mouse Host: HEK-293 Cells Recombinant >95 % (SDS-PAGE) SDS Active
Catalog No. ABIN1344234
  • Target See all BCMA (TNFRSF17) Proteins
    BCMA (TNFRSF17) (Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Protein Characteristics
    Extracellular Domain, AA 2-54
    Origin
    • 42
    • 12
    • 6
    • 6
    • 2
    • 1
    • 1
    Human, Mouse
    Source
    • 42
    • 8
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This BCMA protein is labelled with Fc Tag.
    Application
    SDS-PAGE (SDS)
    Specificity
    Binds human and mouse BAFF and APRIL.
    Cross-Reactivity
    Human, Mouse (Murine)
    Characteristics
    The extracellular domain of human BCMA (aa 2-54) is fused at the C-terminus to the Fc portion of human IgG1.
    Purity
    >95 % (SDS-PAGE)
    Endotoxin Level
    <0.01EU/μg purified protein (LAL test, Lonza).
    Top Product
    Discover our top product TNFRSF17 Protein
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Comment

    Blocks the binding of BAFF and APRIL to their receptors BCMA and TACI, inhibiting BAFF- and APRIL-mediated B cell activation.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstitute with 50 μL sterile water.
    Concentration
    Lot specific
    Buffer
    Lyophilized. Contains PBS.
    Storage
    4 °C,-20 °C
    Storage Comment
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 6 months after receipt when stored at -20°C.
    Expiry Date
    6 months
  • Huard, Tran, Benkhoucha, Manzin-Lorenzi, Santiago-Raber: "Selective APRIL blockade delays systemic lupus erythematosus in mouse." in: PLoS ONE, Vol. 7, Issue 2, pp. e31837, (2012) (PubMed).

    Huard, Arlettaz, Ambrose, Kindler, Mauri, Roosnek, Tschopp, Schneider, French: "BAFF production by antigen-presenting cells provides T cell co-stimulation." in: International immunology, Vol. 16, Issue 3, pp. 467-75, (2004) (PubMed).

    Huard, Schneider, Mauri, Tschopp, French: "T cell costimulation by the TNF ligand BAFF." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 11, pp. 6225-31, (2001) (PubMed).

    Rennert, Schneider, Cachero, Thompson, Trabach, Hertig, Holler, Qian, Mullen, Strauch, Browning, Ambrose, Tschopp: "A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL, inhibits tumor cell growth." in: The Journal of experimental medicine, Vol. 192, Issue 11, pp. 1677-84, (2000) (PubMed).

  • Target
    BCMA (TNFRSF17) (Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17))
    Alternative Name
    BCMA (TNFRSF17 Products)
    Synonyms
    TNFRSF17 Protein, BCM Protein, BCMA Protein, CD269 Protein, TNFRSF13A Protein, Tnfrsf13 Protein, Tnfrsf13a Protein, TNF receptor superfamily member 17 Protein, tumor necrosis factor receptor superfamily, member 17 Protein, Tnfrsf17 Protein, TNFRSF17 Protein
    Background
    BCMA is a receptor for BAFF and APRIL. It promotes B cell survival and plays a role in the regulation of humoral immunity. Its downstream signaling is dependent on NF-kappaB and JNK.
    Molecular Weight
    ~40kDa (SDS-PAGE)
    UniProt
    Q02223
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