NOX3 antibody (C-Term)

Catalog No. ABIN966688

Product Details anti-NOX3 Antibody

Target: NOX3 (NADPH Oxidase 3 (NOX3))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NOX3 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human NOX3(NADPH oxidase 3)

Application Details

Restrictions: For Research Use only

Handling

Storage: 4 °C

References for anti-NOX3 antibody (ABIN966688)

Ueno, Takeya, Miyano, Kikuchi, Sumimoto: "The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators." in: The Journal of biological chemistry, Vol. 280, Issue 24, pp. 23328-39, (2005) (PubMed).

Cheng, Ritsick, Lambeth: "Nox3 regulation by NOXO1, p47phox, and p67phox." in: The Journal of biological chemistry, Vol. 279, Issue 33, pp. 34250-5, (2004) (PubMed).

Cheng, Cao, Xu, van Meir, Lambeth: "Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5." in: Gene, Vol. 269, Issue 1-2, pp. 131-40, (2001) (PubMed).

Target Details for NOX3

Target: NOX3 (NADPH Oxidase 3 (NOX3))

Alternative Name: NOX3 (NOX3 Products)

Background: NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. NOX3(NADPH oxidase 3) plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. NOX3(NADPH oxidase 3) is activated by the ototoxic drug cisplatin and by NOXO1. NOX3 is cooperatively activated by NCF1 and NCF2 or NOXA1 in a phorbol 12-myristate 13-acetate (PMA)-dependent manner. It is inhibited by diphenyleneiodonium chloride and interacts with and stabilizes CYBA/p22phox. NOX3 is expressed in fetal kidney and to a lower extent in liver, lung and spleen.
Synonyms: MOX2