Endoglin antibody (FITC)

Catalog No. ABIN610351

Product Details anti-Endoglin Antibody (FITC)

Target: Endoglin (ENG)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Endoglin antibody is conjugated to FITC

Application: Flow Cytometry (FACS), Immunohistochemistry (IHC), Functional Studies (Func)

Specificity: CD105 homodimer with a molecular weight of about 160 kd.

Purification: Protein A purified

Immunogen: Membrane preparation of human B-lineage leukemia cells.

Clone: SN6-N1-3A1

Isotype: IgG1 kappa

Application Details

Application Notes: Approved: Flo, Func, IHC

Usage: Function: Augments binding of TGF-b1 to CD105 expressing leukemia cells. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 50 mM sodium phosphate,  pH 7.5, 100 mM potassium chloride, 150 mM sodium chloride, 5 % Glycerol, 0.2 % BSA, 0.04 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze. Product is photosensitive and should be protected from light.

Storage: 4 °C

Storage Comment: Store at 4°C. Do not freeze. Protect from light.

References for anti-Endoglin antibody (FITC) (ABIN610351)

Tao, Malbon, Wang: "Galpha(i2) enhances insulin signaling via suppression of protein-tyrosine phosphatase 1B." in: The Journal of biological chemistry, Vol. 276, Issue 43, pp. 39705-12, (2001) (PubMed).

Arnott, Sale, Miller, Sale: "Use of an antisense strategy to dissect the signaling role of protein-tyrosine phosphatase alpha." in: The Journal of biological chemistry, Vol. 274, Issue 37, pp. 26105-12, (1999) (PubMed).

Longo, Martignetti, Le Beau, Zhang, Barnes, Brosius: "Leukocyte common antigen-related receptor-linked tyrosine phosphatase. Regulation of mRNA expression." in: The Journal of biological chemistry, Vol. 268, Issue 35, pp. 26503-11, (1994) (PubMed).

Target Details for Endoglin

Target: Endoglin (ENG)

Alternative Name: CD105 (ENG Products)

Synonyms: ENG antibody, MGC137842 antibody, DKFZp469D0419 antibody, END antibody, HHT1 antibody, ORW1 antibody, AI528660 antibody, AI662476 antibody, CD105 antibody, S-endoglin antibody, endoglin antibody, ENG antibody, Eng antibody

Background: Name/Gene ID: ENG

Synonyms: ENG, CD105, CD105 antigen, END, HHT1, ORW, ORW1, Osler-Rendu-Weber syndrome 1, Endoglin

Gene ID: 2022

UniProt: P17813