HLA-DR antibody

Catalog No. ABIN1526070

Product Details anti-HLA-DR Antibody

Target: HLA-DR

Reactivity: Human, Dog, Primate

Host: Mouse

Clonality: Monoclonal

Conjugate: This HLA-DR antibody is un-conjugated

Application: Flow Cytometry (FACS), Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Functional Studies (Func)

Cross-Reactivity (Details): Species reactivity (tested):Human, Non-Human Primates, Canine (Dog)

Purification: Protein-A affinity chromatography

Clone: L243

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, pH ~7.4, 15 mM Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

References for anti-HLA-DR antibody (ABIN1526070)

Ezoe, Daikoku, Yabuuchi, Murata, Kawano, Abe, Okuno, Kobayashi, Kato: "Ovarian stimulation using human chorionic gonadotrophin impairs blastocyst implantation and decidualization by altering ovarian hormone levels and downstream signaling in mice." in: Molecular human reproduction, Vol. 20, Issue 11, pp. 1101-16, (2015) (PubMed).

Ivanov, Beers, Walshe, Honeychurch, Alduaij, Cox, Potter, Murray, Chan, Klymenko, Erenpreisa, Glennie, Illidge, Cragg: "Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells." in: The Journal of clinical investigation, Vol. 119, Issue 8, pp. 2143-59, (2009) (PubMed).

De Gassart, Camosseto, Thibodeau, Ceppi, Catalan, Pierre, Gatti: "MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 9, pp. 3491-6, (2008) (PubMed).

Swiatek-de Lange, Rist, Stahl, Weith, Lenter: "Comment on "MHC class II expression identifies functionally distinct human regulatory T cells"." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 6, pp. 3625; author reply 3626, (2008) (PubMed).

Bouillon, El Fakhry, Girouard, Khalil, Thibodeau, Mourad: "Lipid raft-dependent and -independent signaling through HLA-DR molecules." in: The Journal of biological chemistry, Vol. 278, Issue 9, pp. 7099-107, (2003) (PubMed).

Muczynski, Ekle, Coder, Anderson: "Normal human kidney HLA-DR-expressing renal microvascular endothelial cells: characterization, isolation, and regulation of MHC class II expression." in: Journal of the American Society of Nephrology : JASN, Vol. 14, Issue 5, pp. 1336-48, (2003) (PubMed).

Kalka-Moll, Tzianabos, Bryant, Niemeyer, Ploegh, Kasper: "Zwitterionic polysaccharides stimulate T cells by MHC class II-dependent interactions." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 11, pp. 6149-53, (2002) (PubMed).

Cantin, Martin, Tremblay et al.: "A novel virus capture assay reveals a differential acquisition of host HLA-DR by clinical isolates of human immunodeficiency virus type 1 expanded in primary human cells depending on the nature of ..." in: The Journal of general virology, Vol. 82, Issue Pt 12, pp. 2979-87, (2001) (PubMed).

Schmitz, Weissenbach, Haan, Heinrich, Schaper: "SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130." in: The Journal of biological chemistry, Vol. 275, Issue 17, pp. 12848-56, (2000) (PubMed).

Gabbert, Mueller, Schneiders, Meier, Moll, Birchmeier, Hommel: "Prognostic value of E-cadherin expression in 413 gastric carcinomas." in: International journal of cancer. Journal international du cancer, Vol. 69, Issue 3, pp. 184-9, (1996) (PubMed).

Target Details for HLA-DR

Target: HLA-DR

Alternative Name: HLA Class II DR (HLA-DR Products)

Background: HLA-DR, a member of MHC class II glycoproteins, that bind intracellularly processed peptides and present them to the Th cells, is composed of 36 kDa alpha chain and 27 kDa beta chain, both anchored in the plasma membrane. Together with other MHC II molecules HLA-DR plays a central role in the immune system. It is expressed on antigen-presenting cells (dendritic cells, B lymphocytes, monocytes, macrophages).Synonyms: HLA class II histocompatibility antigen DR, HLA-DR, MHC class II antigen DR