CHRNA9 antibody (N-Term)

Catalog No. ABIN1944733

Product Details anti-CHRNA9 Antibody

Target: CHRNA9 (Cholinergic Receptor, Nicotinic, alpha 9 (Neuronal) (CHRNA9))

Binding Specificity: AA 8-42, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHRNA9 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CHRNA9 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 8-42 amino acids from the N-terminal region of human CHRNA9.

Clone: RB46802

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. FC: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-CHRNA9 antibody (ABIN1944733)

Hillier, Graves, Fulton, Fulton, Pepin, Minx, Wagner-McPherson, Layman, Wylie, Sekhon, Becker, Fewell, Delehaunty, Miner, Nash, Kremitzki, Oddy, Du, Sun, Bradshaw-Cordum, Ali, Carter, Cordes, Harris et al.: "Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ..." in: Nature, Vol. 434, Issue 7034, pp. 724-31, (2005) (PubMed).

Peng, Ferris, Matthews, Hiel, Lopez-Albaitero, Lustig: "Characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) and alpha (alpha) 10 (CHRNA10) in lymphocytes." in: Life sciences, Vol. 76, Issue 3, pp. 263-80, (2004) (PubMed).

Lustig, Peng: "Chromosome location and characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) gene." in: Cytogenetic and genome research, Vol. 98, Issue 2-3, pp. 154-9, (2003) (PubMed).

Sgard, Charpantier, Bertrand, Walker, Caput, Graham, Bertrand, Besnard: "A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit." in: Molecular pharmacology, Vol. 61, Issue 1, pp. 150-9, (2001) (PubMed).

Nguyen, Ndoye, Grando: "Novel human alpha9 acetylcholine receptor regulating keratinocyte adhesion is targeted by Pemphigus vulgaris autoimmunity." in: The American journal of pathology, Vol. 157, Issue 4, pp. 1377-91, (2000) (PubMed).

Target Details for CHRNA9

Target: CHRNA9 (Cholinergic Receptor, Nicotinic, alpha 9 (Neuronal) (CHRNA9))

Alternative Name: CHRNA9 (CHRNA9 Products)

Synonyms: HSA243342 antibody, NACHRA9 antibody, 2410015I05Rik antibody, Acra9 antibody, EG666827 antibody, Gm8311 antibody, cholinergic receptor nicotinic alpha 9 subunit antibody, cholinergic receptor, nicotinic, alpha polypeptide 9 antibody, CHRNA9 antibody, Chrna9 antibody

Background: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion.

Molecular Weight: 54807

Gene ID: 55584

UniProt: Q9UGM1

Pathways: Sensory Perception of Sound