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RENT1/UPF1 antibody (N-Term)

UPF1 Reactivity: Human WB Host: Rabbit Polyclonal RB8018 unconjugated
Catalog No. ABIN1882125
  • Target See all RENT1/UPF1 (UPF1) Antibodies
    RENT1/UPF1 (UPF1) (UPF1 Regulator of Nonsense Transcripts Homolog (UPF1))
    Binding Specificity
    • 15
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 7-37, N-Term
    Reactivity
    • 48
    • 15
    • 6
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 42
    • 3
    • 3
    Rabbit
    Clonality
    • 40
    • 8
    Polyclonal
    Conjugate
    • 30
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This RENT1/UPF1 antibody is un-conjugated
    Application
    • 26
    • 18
    • 14
    • 14
    • 9
    • 8
    • 7
    • 7
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Predicted Reactivity
    M
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This RENT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7-37 amino acids from the N-terminal region of human RENT1.
    Clone
    RB8018
    Isotype
    Ig Fraction
    Top Product
    Discover our top product UPF1 Primary Antibody
  • Application Notes
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Kang, Shen, Macdonald: "Two molecular pathways (NMD and ERAD) contribute to a genetic epilepsy associated with the GABA(A) receptor GABRA1 PTC mutation, 975delC, S326fs328X." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 29, Issue 9, pp. 2833-44, (2009) (PubMed).

    Ohnishi, Yamashita, Kashima, Schell, Anders, Grimson, Hachiya, Hentze, Anderson, Ohno: "Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7." in: Molecular cell, Vol. 12, Issue 5, pp. 1187-200, (2003) (PubMed).

    Mendell, ap Rhys, Dietz: "Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts." in: Science (New York, N.Y.), Vol. 298, Issue 5592, pp. 419-22, (2002) (PubMed).

    Lykke-Andersen: "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay." in: Molecular and cellular biology, Vol. 22, Issue 23, pp. 8114-21, (2002) (PubMed).

    Carastro, Tan, Selg, Jack, So, Downey: "Identification of delta helicase as the bovine homolog of HUPF1: demonstration of an interaction with the third subunit of DNA polymerase delta." in: Nucleic acids research, Vol. 30, Issue 10, pp. 2232-43, (2002) (PubMed).

  • Target
    RENT1/UPF1 (UPF1) (UPF1 Regulator of Nonsense Transcripts Homolog (UPF1))
    Alternative Name
    RENT1 (UPF1 Products)
    Synonyms
    HUPF1 antibody, NORF1 antibody, RENT1 antibody, pNORF1 antibody, smg-2 antibody, B430202H16Rik antibody, PNORF-1 antibody, Rent1 antibody, Upflp antibody, rent1 antibody, wu:fi40f07 antibody, wu:fj48a01 antibody, zgc:55472 antibody, Tb05.3C6.50 antibody, AO090012000584 antibody, hupf1 antibody, norf1 antibody, pnorf1 antibody, upf1 antibody, UPF1, RNA helicase and ATPase antibody, UPF1 regulator of nonsense transcripts homolog (yeast) antibody, upf1 regulator of nonsense transcripts homolog (yeast) antibody, regulator of nonsense transcripts 1 antibody, Regulator of nonsense transcripts 1 antibody, UPF1 regulator of nonsense transcripts homolog S homeolog antibody, UPF1 antibody, Upf1 antibody, upf1 antibody, Tc00.1047053511317.30 antibody, Tb927.5.2140 antibody, TVAG_453890 antibody, TVAG_237840 antibody, AOR_1_1018194 antibody, HPB8_739 antibody, smg-2 antibody, upf1.S antibody
    Background
    RENT1 is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping.
    Molecular Weight
    124345
    NCBI Accession
    NP_002902
    UniProt
    Q92900
    Pathways
    SARS-CoV-2 Protein Interactome
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