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PDE6H antibody (AA 4-33)

PDE6H Reactivity: Mouse WB Host: Rabbit Polyclonal RB40887 unconjugated
Catalog No. ABIN1881645
  • Target See all PDE6H Antibodies
    PDE6H (phosphodiesterase 6H, CGMP-Specific, Cone, gamma (PDE6H))
    Binding Specificity
    • 7
    • 5
    AA 4-33
    Reactivity
    • 7
    • 7
    Mouse
    Host
    • 12
    Rabbit
    Clonality
    • 12
    Polyclonal
    Conjugate
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    This PDE6H antibody is un-conjugated
    Application
    • 10
    • 7
    • 1
    Western Blotting (WB)
    Predicted Reactivity
    B, Rat, H
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This PDE6H antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-33 amino acids from the Central region of human PDE6H.
    Clone
    RB40887
    Isotype
    Ig Fraction
  • Application Notes
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Piri, Gao, Danciger, Mendoza, Fishman, Farber: "A substitution of G to C in the cone cGMP-phosphodiesterase gamma subunit gene found in a distinctive form of cone dystrophy." in: Ophthalmology, Vol. 112, Issue 1, pp. 159-66, (2005) (PubMed).

    Kajimura, Yamazaki, Morikawa, Yamazaki, Mayanagi: "Three-dimensional structure of non-activated cGMP phosphodiesterase 6 and comparison of its image with those of activated forms." in: Journal of structural biology, Vol. 139, Issue 1, pp. 27-38, (2002) (PubMed).

    Shimizu-Matsumoto, Itoh, Inazawa, Nishida, Matsumoto, Kinoshita, Matsubara, Okubo: "Isolation and chromosomal localization of the human cone cGMP phosphodiesterase gamma cDNA (PDE6H)." in: Genomics, Vol. 32, Issue 1, pp. 121-4, (1996) (PubMed).

    Hanna, Kruskal, Ezekowitz, Bloom, Collier: "Role of macrophage oxidative burst in the action of anthrax lethal toxin." in: Molecular medicine (Cambridge, Mass.), Vol. 1, Issue 1, pp. 7-18, (1996) (PubMed).

  • Target
    PDE6H (phosphodiesterase 6H, CGMP-Specific, Cone, gamma (PDE6H))
    Alternative Name
    PDE6H (PDE6H Products)
    Synonyms
    ACHM6 antibody, RCD3 antibody, A930033D18Rik antibody, PDEgamma antibody, Pde6g antibody, phosphodiesterase 6H antibody, phosphodiesterase 6H, cGMP-specific, cone, gamma antibody, PDE6H antibody, Pde6h antibody
    Background
    This gene encodes the inhibitory (or gamma) subunit of the cone-specific cGMP phosphodiesterase, which is a tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma). It is specifically expressed in the retina, and is involved in the transmission and amplification of the visual signal. Mutations in this gene are associated with retinal cone dystrophy type 3A (RCD3A).
    Molecular Weight
    9074
    NCBI Accession
    NP_006196
    UniProt
    Q13956
    Pathways
    EGFR Signaling Pathway, Regulation of G-Protein Coupled Receptor Protein Signaling
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