Tryptophan Hydroxylase 2 antibody (N-Term)

Catalog No. ABIN2778285

Product Details anti-Tryptophan Hydroxylase 2 Antibody

Target: Tryptophan Hydroxylase 2 (TPH2)

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Dog, Cow, Horse, Pig, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Tryptophan Hydroxylase 2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: REAATESGKT AVVFSLKNEV GGLVKALRLF QEKRVNMVHI ESRKSRRRSS

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 83%, Horse: 85%, Human: 100%, Mouse: 92%, Pig: 100%, Rabbit: 100%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against TPH2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TPH2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 490 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-Tryptophan Hydroxylase 2 antibody (ABIN2778285)

Walther, Peter, Bashammakh, Hörtnagl, Voits, Fink, Bader: "Synthesis of serotonin by a second tryptophan hydroxylase isoform." in: Science (New York, N.Y.), Vol. 299, Issue 5603, pp. 76, (2003) (PubMed).

Target Details for Tryptophan Hydroxylase 2

Target: Tryptophan Hydroxylase 2 (TPH2)

Alternative Name: TPH2 (TPH2 Products)

Synonyms: ADHD7 antibody, NTPH antibody, Ntph antibody, tphR antibody, wu:fq15a04 antibody, AU043594 antibody, tryptophan hydroxylase 2 antibody, tryptophan hydroxylase 2 (tryptophan 5-monooxygenase) antibody, TPH2 antibody, Tph2 antibody, tph2 antibody

Background: Tryptophan hydroxylase (TPH, EC 1.14.16.4) is the rate-limiting enzyme in the synthesis of serotonin (5-hydroxytryptamine, or 5HT). 5HT is causally involved in numerous central nervous activities, and it has several functions in peripheral tissues, including the maintenance of vascular tone and gut motility.
Alias Symbols: NTPH, ADHD7
Protein Interaction Partner: UBC,
Protein Size: 490

Molecular Weight: 56 kDa

Gene ID: 121278

NCBI Accession: NM_173353, NP_775489

UniProt: Q8IWU9