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TNF alpha antibody

TNF alpha Reactivity: Human ELISA, IHC, Func, ELISpot Host: Mouse Monoclonal B-C7 unconjugated
Catalog No. ABIN1383955
  • Target See all TNF alpha Antibodies
    TNF alpha (Tumor Necrosis Factor alpha (TNF alpha))
    Reactivity
    • 323
    • 182
    • 123
    • 67
    • 50
    • 42
    • 27
    • 26
    • 23
    • 16
    • 12
    • 10
    • 10
    • 9
    • 6
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 262
    • 192
    • 31
    • 25
    • 6
    • 2
    • 2
    Mouse
    Clonality
    • 278
    • 233
    Monoclonal
    Conjugate
    • 248
    • 86
    • 45
    • 20
    • 17
    • 12
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This TNF alpha antibody is un-conjugated
    Application
    • 348
    • 209
    • 128
    • 122
    • 74
    • 62
    • 58
    • 49
    • 48
    • 40
    • 39
    • 37
    • 37
    • 32
    • 20
    • 11
    • 10
    • 9
    • 9
    • 6
    • 6
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC), Functional Studies (Func), ELISpot
    Specificity
    Recognises both natural and recombinant human TNF-a
    Purification
    Ion exchange chromatography
    Sterility
    0.22 μm filtered
    Immunogen
    Recombinant human TNF-a,Myeloma X63/AG.8653 x Balb/c spleen cells
    Clone
    B-C7
    Isotype
    IgG1 kappa
    Biological Activity Comment
    Inhibits TNFα induced cytotoxicity on U937 cells
    Top Product
    Discover our top product TNF alpha Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Phosphate-buffered saline. Sterile-filtered through 0.22 μm. Carrier and preservative free
    Preservative
    Without preservative
    Storage
    4 °C
    Storage Comment
    Store at +2-8°C for 12 months. DO NOT FREEZE.
  • Arduise, Abache, Li, Billard, Chabanon, Ludwig, Mauduit, Boucheix, Rubinstein, Le Naour: "Tetraspanins regulate ADAM10-mediated cleavage of TNF-alpha and epidermal growth factor." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 10, pp. 7002-13, (2008) (PubMed).

    Venet, Pachot, Debard, Bohe, Bienvenu, Lepape, Powell, Monneret: "Human CD4+CD25+ regulatory T lymphocytes inhibit lipopolysaccharide-induced monocyte survival through a Fas/Fas ligand-dependent mechanism." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 9, pp. 6540-7, (2006) (PubMed).

    Dyugovskaya, Lavie, Lavie: "Phenotypic and functional characterization of blood gammadelta T cells in sleep apnea." in: American journal of respiratory and critical care medicine, Vol. 168, Issue 2, pp. 242-9, (2003) (PubMed).

    Limb, Daniels, Pleass, Charteris, Luthert, Khaw: "Differential expression of matrix metalloproteinases 2 and 9 by glial Müller cells: response to soluble and extracellular matrix-bound tumor necrosis factor-alpha." in: The American journal of pathology, Vol. 160, Issue 5, pp. 1847-55, (2002) (PubMed).

    Hamacher, Lucas, Lijnen, Buschke, Dunant, Wendel, Grau, Suter, Ricou: "Tumor necrosis factor-alpha and angiostatin are mediators of endothelial cytotoxicity in bronchoalveolar lavages of patients with acute respiratory distress syndrome." in: American journal of respiratory and critical care medicine, Vol. 166, Issue 5, pp. 651-6, (2002) (PubMed).

    Musey, Ding, Cao, Lee, Galloway, Yuen, Jerome, McElrath: "Ontogeny and specificities of mucosal and blood human immunodeficiency virus type 1-specific CD8(+) cytotoxic T lymphocytes." in: Journal of virology, Vol. 77, Issue 1, pp. 291-300, (2002) (PubMed).

    Marfaing-Koka, Maravic, Humbert, Galanaud, Emilie: "Contrasting effects of IL-4, IL-10 and corticosteroids on RANTES production by human monocytes." in: International immunology, Vol. 8, Issue 10, pp. 1587-94, (1997) (PubMed).

    Voorzanger, Touitou, Garcia, Delecluse, Rousset, Joab, Favrot, Blay: "Interleukin (IL)-10 and IL-6 are produced in vivo by non-Hodgkin's lymphoma cells and act as cooperative growth factors." in: Cancer research, Vol. 56, Issue 23, pp. 5499-505, (1997) (PubMed).

    Mey, Hmama, Normier, Revillard: "Alteration of dealcylated lipopolysaccharide antagonistic properties by interaction with plasma factors." in: Journal of leukocyte biology, Vol. 61, Issue 1, pp. 17-23, (1997) (PubMed).

    Ida, Robertson, Voss, Ritz, Anderson: "CD94 ligation induces apoptosis in a subset of IL-2-stimulated NK cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 159, Issue 5, pp. 2154-60, (1997) (PubMed).

    van Hensbroek, Palmer, Onyiorah, Schneider, Jaffar, Dolan, Memming, Frenkel, Enwere, Bennett, Kwiatkowski, Greenwood: "The effect of a monoclonal antibody to tumor necrosis factor on survival from childhood cerebral malaria." in: The Journal of infectious diseases, Vol. 174, Issue 5, pp. 1091-7, (1996) (PubMed).

    Racadot, Milpied, Bordigoni, Cahn, Plouvier, Lioure, Lutz, Wijdenes, Herve: "Sequential use of three monoclonal antibodies in corticosteroid-resistant acute GVHD: a multicentric pilot study including 15 patients." in: Bone marrow transplantation, Vol. 15, Issue 5, pp. 669-77, (1995) (PubMed).

    Boillot, Capellier, Racadot, Wijdenes, Herve, Barale: "Pilot clinical trial of an anti-TNF alpha monoclonal antibody for the treatment of septic shock." in: Clinical intensive care : international journal of critical & coronary care medicine, Vol. 6, Issue 2, pp. 52-6, (1995) (PubMed).

    Hervé, Flesch, Tiberghien, Wijdenes, Racadot, Bordigoni, Plouvier, Stephan, Bourdeau, Holler: "Phase I-II trial of a monoclonal anti-tumor necrosis factor alpha antibody for the treatment of refractory severe acute graft-versus-host disease." in: Blood, Vol. 79, Issue 12, pp. 3362-8, (1992) (PubMed).

    Hervé, Racadot, Wijdenes, Flesch, Tiberghien, Bordigoni, Holler, Powles, Bourdeau, Wilmer: "Monoclonal anti TNF alpha antibody in the treatment of acute GvHD refractory both to corticosteroids and anti IL-2 R antibody." in: Bone marrow transplantation, Vol. 7 Suppl 2, pp. 149, (1991) (PubMed).

  • Target
    TNF alpha (Tumor Necrosis Factor alpha (TNF alpha))
    Alternative Name
    TNF alpha (TNF alpha Products)
    Synonyms
    DIF antibody, TNF-alpha antibody, TNFA antibody, TNFSF2 antibody, RATTNF antibody, Tnfa antibody, tnf antibody, TNF-a antibody, TNFalpha antibody, Tnfsf1a antibody, TNFa antibody, cTNF antibody, Tnf-alpha antibody, tnfa-like antibody, TNF-ALPHA antibody, dif antibody, tnfa antibody, xtnf antibody, tnfsf2 antibody, tnf-alpha antibody, Cachectin antibody, tumor necrosis factor antibody, tumor necrosis factor b (TNF superfamily, member 2) antibody, tumor necrosis factor alpha antibody, tumor necrosis factor a (TNF superfamily, member 2) antibody, TNF antibody, Tnf antibody, tnf antibody, tnfb antibody, tnf-alpha antibody, LOC103694380 antibody, tnfa antibody
    Background
    TNFa
    Pathways
    NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, TLR Signaling, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Inflammasome
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