UBE3C antibody (AA 549-578)

Catalog No. ABIN1881969

Product Details anti-UBE3C Antibody

Target: UBE3C (Ubiquitin Protein Ligase E3C (UBE3C))

Binding Specificity: AA 549-578

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBE3C antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This UBE3C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 549-578 amino acids from the Central region of human UBE3C.

Clone: RB44044

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-UBE3C antibody (ABIN1881969)

Hillier, Fulton, Fulton, Graves, Pepin, Wagner-McPherson, Layman, Maas, Jaeger, Walker, Wylie, Sekhon, Becker, OLaughlin, Schaller, Fewell, Delehaunty, Miner, Nash, Cordes, Du, Sun, Edwards et al.: "The DNA sequence of human chromosome 7. ..." in: Nature, Vol. 424, Issue 6945, pp. 157-64, (2003) (PubMed).

Scherer, Cheung, MacDonald, Osborne, Nakabayashi, Herbrick, Carson, Parker-Katiraee, Skaug, Khaja, Zhang, Hudek, Li, Haddad, Duggan, Fernandez, Kanematsu, Gentles, Christopoulos, Choufani, Kwasnicka et al.: "Human chromosome 7: DNA sequence and biology. ..." in: Science (New York, N.Y.), Vol. 300, Issue 5620, pp. 767-72, (2003) (PubMed).

You, Pickart: "A HECT domain E3 enzyme assembles novel polyubiquitin chains." in: The Journal of biological chemistry, Vol. 276, Issue 23, pp. 19871-8, (2001) (PubMed).

Target Details for UBE3C

Target: UBE3C (Ubiquitin Protein Ligase E3C (UBE3C))

Alternative Name: UBE3C (UBE3C Products)

Synonyms: UBE3C antibody, RGD1559986 antibody, zgc:63649 antibody, AI853514 antibody, mKIAA0010 antibody, HECTH2 antibody, kiaa0010 antibody, MGC146390 antibody, ubiquitin protein ligase E3C antibody, ubiquitin protein ligase E3C S homeolog antibody, UBE3C antibody, Ube3c antibody, ube3c antibody, ube3c.S antibody

Background: E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'-or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.

Molecular Weight: 123923

NCBI Accession: NP_055486

UniProt: Q15386