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PTK2B antibody (AA 815-997)

PTK2B Reactivity: Human WB, ELISA, IHC Host: Mouse Monoclonal 5E2D5 unconjugated
Catalog No. ABIN1724705
  • Target See all PTK2B Antibodies
    PTK2B (PTK2B Protein tyrosine Kinase 2 beta (PTK2B))
    Binding Specificity
    • 24
    • 21
    • 17
    • 15
    • 10
    • 7
    • 6
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 815-997
    Reactivity
    • 115
    • 113
    • 96
    • 8
    • 7
    • 7
    • 6
    • 5
    • 5
    • 5
    • 1
    • 1
    • 1
    Human
    Host
    • 146
    • 12
    • 3
    Mouse
    Clonality
    • 141
    • 20
    Monoclonal
    Conjugate
    • 75
    • 11
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    This PTK2B antibody is un-conjugated
    Application
    • 123
    • 58
    • 43
    • 40
    • 39
    • 26
    • 13
    • 13
    • 9
    • 4
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Purification
    purified
    Immunogen
    Purified recombinant fragment of PYK2 (aa815-997) expressed in E. coli.
    Clone
    5E2D5
    Isotype
    IgG2a
    Top Product
    Discover our top product PTK2B Primary Antibody
  • Application Notes
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    4°C, -20°C for long term storage
  • Dylla, Deyle, Theunissen, Padurean, Verfaillie: "Integrin engagement-induced inhibition of human myelopoiesis is mediated by proline-rich tyrosine kinase 2 gene products." in: Experimental hematology, Vol. 32, Issue 4, pp. 365-74, (2004) (PubMed).

    Haglund, Ivankovic-Dikic, Shimokawa, Kruh, Dikic: "Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites." in: Journal of cell science, Vol. 117, Issue Pt 12, pp. 2557-68, (2004) (PubMed).

    van der Horst, Weber, Ullrich: "Tyrosine phosphorylation of PYK2 mediates heregulin-induced glioma invasion: novel heregulin/HER3-stimulated signaling pathway in glioma." in: International journal of cancer. Journal international du cancer, Vol. 113, Issue 5, pp. 689-98, (2004) (PubMed).

  • Target
    PTK2B (PTK2B Protein tyrosine Kinase 2 beta (PTK2B))
    Alternative Name
    PYK2 (PTK2B Products)
    Synonyms
    CADTK antibody, CAKB antibody, FADK2 antibody, FAK2 antibody, PKB antibody, PTK antibody, PYK2 antibody, RAFTK antibody, CAKbeta antibody, E430023O05Rik antibody, Raftk antibody, Pyk2 antibody, fak1b antibody, ptk2.2 antibody, ptk2b antibody, si:ch1073-355e8.1 antibody, protein tyrosine kinase 2 beta antibody, PTK2 protein tyrosine kinase 2 beta antibody, protein tyrosine kinase 2aa antibody, PTK2B antibody, Ptk2b antibody, ptk2aa antibody
    Background

    Description: PYK2: PTK2B protein tyrosine kinase 2 beta, also known as PTK2B, PKB, PTK, CAKB, FAK2, FRNK. Entrez Protein NP_004094. It is a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.

    Aliases: PKB, PTK, CAKB, FAK2, FRNK, PTK2B

    Molecular Weight
    115.8 kDa
    Gene ID
    2185
    NCBI Accession
    NP_004094
    HGNC
    2185
    Pathways
    EGFR Signaling Pathway, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Cellular Glucan Metabolic Process, Cell-Cell Junction Organization, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, Positive Regulation of fat Cell Differentiation, VEGF Signaling
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