GUCA1B antibody (N-Term)

Catalog No. ABIN1881399

Product Details anti-GUCA1B Antibody

Target: GUCA1B (Guanylate Cyclase Activator 1B (Retina) (GUCA1B))

Binding Specificity: AA 29-57, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GUCA1B antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This GUCA1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-57 amino acids from the N-terminal region of human GUCA1B.

Clone: RB40485

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-GUCA1B antibody (ABIN1881399)

Sato, Nakazawa, Usui, Tanimoto, Abe, Ohguro: "Mutations in the gene coding for guanylate cyclase-activating protein 2 (GUCA1B gene) in patients with autosomal dominant retinal dystrophies." in: Graefe's archive for clinical and experimental ophthalmology, Vol. 243, Issue 3, pp. 235-42, (2005) (PubMed).

Nishiguchi, Sokal, Yang, Roychowdhury, Palczewski, Berson, Dryja, Baehr: "A novel mutation (I143NT) in guanylate cyclase-activating protein 1 (GCAP1) associated with autosomal dominant cone degeneration." in: Investigative ophthalmology & visual science, Vol. 45, Issue 11, pp. 3863-70, (2004) (PubMed).

Mungall, Palmer, Sims, Edwards, Ashurst, Wilming, Jones, Horton, Hunt, Scott, Gilbert, Clamp, Bethel, Milne, Ainscough, Almeida, Ambrose, Andrews, Ashwell, Babbage, Bagguley, Bailey, Banerjee, Barker et al.: "The DNA sequence and analysis of human chromosome 6. ..." in: Nature, Vol. 425, Issue 6960, pp. 805-11, (2003) (PubMed).

Target Details for GUCA1B

Target: GUCA1B (Guanylate Cyclase Activator 1B (Retina) (GUCA1B))

Alternative Name: GUCA1B (GUCA1B Products)

Synonyms: GUCA1B antibody, BC018258 antibody, GCAP2 antibody, GUCA2 antibody, RP48 antibody, guanylate cyclase activator 1B antibody, guanylate cyclase activator 1B (retina) antibody, GUCA1B antibody, guca1b antibody, Guca1b antibody

Background: The protein encoded by this gene is a calcium-binding protein that activates photoreceptor guanylate cyclases. This gene may have arisen due to a gene duplication event since there is a highly similar gene clustered with it on chromosome 6. Mutations in this gene can cause a form of retinitis pigmentosa. [provided by RefSeq].

Molecular Weight: 23420

NCBI Accession: NP_002089

UniProt: Q9UMX6

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction