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BMX antibody

BMX Reactivity: Human WB, ELISA Host: Mouse Monoclonal 1C6 unconjugated
Catalog No. ABIN968989
  • Target See all BMX Antibodies
    BMX (BMX Non-Receptor Tyrosine Kinase (BMX))
    Reactivity
    • 58
    • 50
    • 21
    • 5
    • 1
    • 1
    • 1
    Human
    Host
    • 73
    • 1
    Mouse
    Clonality
    • 73
    • 1
    Monoclonal
    Conjugate
    • 41
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    This BMX antibody is un-conjugated
    Application
    • 71
    • 36
    • 34
    • 26
    • 26
    • 21
    • 16
    • 7
    • 5
    • 4
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA
    Purification
    purified
    Immunogen
    Purified recombinant fragment of human BMX expressed in E. coli.
    Clone
    1C6
    Isotype
    IgG1
    Top Product
    Discover our top product BMX Primary Antibody
  • Application Notes
    ELISA: 1:10000, WB: 1:500 - 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    4°C, -20°C for long term storage
  • Palmer, Mutch, Workman, McDaid, Horwood, Foxwell: "Bmx tyrosine kinase regulates TLR4-induced IL-6 production in human macrophages independently of p38 MAPK and NFkapp}B activity." in: Blood, Vol. 111, Issue 4, pp. 1781-8, (2008) (PubMed).

    Côté, Motoyama, Bush, Vuori: "A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling." in: Nature cell biology, Vol. 7, Issue 8, pp. 797-807, (2005) (PubMed).

  • Target
    BMX (BMX Non-Receptor Tyrosine Kinase (BMX))
    Alternative Name
    BMX (BMX Products)
    Synonyms
    BMX antibody, ETK antibody, PSCTK2 antibody, PSCTK3 antibody, Etk antibody, Etk/Bmx antibody, Tyro8 antibody, RGD1565643 antibody, BMX non-receptor tyrosine kinase antibody, BMX antibody, bmx antibody, Bmx antibody
    Background

    Description: BMX (bone marrow X kinase) is a cytoplasmic tyrosine kinase identified by reverse transcription of mRNA isolated from human bone marrow and mapped to the chromosomal band Xp22.2. The full length protein is 675 amino acids with a tyrosine kinase domain, an amino terminal pleckstrin domain, as well as an SH3 and SH2 domain. Direct comparison of BMX's primary sequence with other kinases showed that this is highly related to the family of BTK/ITK/TEC. BMX kinase is expressed in fetal and adult tissues, with the highest expression in heart, testis, small intestine and colon. It is undetectable in spleen, brain, kidney, and pancreas. Further analysis of mRNA expression showed that BMX is expressed in hematopoietic tissues and neutrophilic granulocytes, and in patients with acute and myeloid leukemia. The levels of BMX mRNA were substantially lower in patients with acute and chronic lymphoid leukemias, thus suggesting that BMX may be important during myelopoiesis.CST:It is expressed in a variety of hematopoietic, epithelial and endothelial cells.

    Aliases: ETK, PSCTK2, PSCTK3, BMX

    Molecular Weight
    78 kDa
    Gene ID
    660
    HGNC
    660
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