EPH Receptor A3 antibody (AA 751-983)

Catalog No. ABIN969101

Product Details anti-EPH Receptor A3 Antibody

Target: EPH Receptor A3 (EPHA3)

Binding Specificity: AA 751-983

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This EPH Receptor A3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: purified

Immunogen: Purified recombinant fragment of EphA3 (aa751-983) expressed in E. coli.

Clone: 6C1B6

Isotype: IgG2b

Application Details

Application Notes: ELISA: 1:10000, WB: 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

References for anti-EPH Receptor A3 antibody (ABIN969101)

Janes, Saha, Barton, Kolev, Wimmer-Kleikamp, Nievergall, Blobel, Himanen, Lackmann, Nikolov: "Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans." in: Cell, Vol. 123, Issue 2, pp. 291-304, (2005) (PubMed).

Target Details for EPH Receptor A3

Target: EPH Receptor A3 (EPHA3)

Alternative Name: EphA3 (EPHA3 Products)

Background:

Description: EphA3: EPH receptor A3. This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene.

Aliases: SEK, HEK8, TYRO1

Gene ID: 2043

HGNC: 2043

Pathways: RTK Signaling, Regulation of Cell Size