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CXCL12 antibody

CXCL12 Reactivity: Human WB, IHC (p), EIA, Func Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN116229
  • Target See all CXCL12 Antibodies
    CXCL12 (Chemokine (C-X-C Motif) Ligand 12 (CXCL12))
    Reactivity
    • 66
    • 23
    • 19
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 81
    • 9
    • 5
    • 2
    Rabbit
    Clonality
    • 84
    • 13
    Polyclonal
    Conjugate
    • 43
    • 16
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CXCL12 antibody is un-conjugated
    Application
    • 75
    • 38
    • 34
    • 13
    • 13
    • 10
    • 9
    • 7
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA), Functional Studies (Func)
    Specificity
    This antibody detects Human Stromal Cell Derived Factor-1 alpha. Other species not tested.
    Purification
    Affinity Chromatography employing immobilized Human SDF1a matrix.
    Immunogen
    Highly pure (>98%) E.coli derived recombinant Human SDF1-alpha.
    Top Product
    Discover our top product CXCL12 Primary Antibody
  • Application Notes
    Neutralization: To yield one-half maximal inhibition [ND50] of the biological activity of hSDF1α (100 ng/mL),a concentration of 2-4 μg/mL of this antibody is required. ELISA: Indirect: Using 100 μL/well antibody solution, a concentration of 0.5-2.0 μg/mL is required. In conjunction with compatible secondary reagents, it allows the detection of at least 0.2 -0.4 ng/well of recombinant hSDF-1α. Sandwich: Using 100 μL/well antibody solution, a concentration of 0.5 - 2.0 μg/mL isrequired. In conjunction with Biotinylated Anti-Human SDF-1α (PP1067B) as a detectionantibody, it allows the detection of at least 0.2-0.4 ng/well of recombinant hSDF-1α. Western Blot: 0.1-0.2 μg/mL. Used in conjunction with compatible secondary reagents the detection limitfor recombinant hSDF-1α is 1.5-3.0 ng/lane, under either reducing or non-reducingconditions.
    Restrictions
    For Research Use only
  • Reconstitution
    Restore in sterile water to a concentration of 0.1-1.0 mg/mL.
    Buffer
    PBS, pH 7.2 without preservatives.
    Preservative
    Without preservative
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C. DO NOT FREEZE! This product is photosensitive and should protected from light.
  • Schlaepfer, Audigé, Joller, Speck: "TLR7/8 triggering exerts opposing effects in acute versus latent HIV infection." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 5, pp. 2888-95, (2006) (PubMed).

  • Target
    CXCL12 (Chemokine (C-X-C Motif) Ligand 12 (CXCL12))
    Alternative Name
    CXCL12 / SDF1 (CXCL12 Products)
    Synonyms
    IRH antibody, PBSF antibody, SCYB12 antibody, SDF1 antibody, TLSF antibody, TPAR1 antibody, CINC-1 antibody, Gro1 antibody, Pbsf antibody, Scyb12 antibody, Sdf1 antibody, Tlsf antibody, Tpar1 antibody, Fsp antibody, KC antibody, Mgsa antibody, N51 antibody, Scyb1 antibody, gro antibody, sdf-1 antibody, sdf1 antibody, xSDF-1 antibody, SDF-1 antibody, cxcl12 antibody, sdf-1a antibody, sdf1a antibody, wu:fa55e10 antibody, wu:fc16h12 antibody, wu:fj84c02 antibody, C-X-C motif chemokine ligand 12 antibody, C-X-C motif chemokine ligand 1 antibody, chemokine (C-X-C motif) ligand 12 antibody, chemokine (C-X-C motif) ligand 1 antibody, C-X-C motif chemokine ligand 12 L homeolog antibody, chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) antibody, CXCL12 antibody, cxcl12 antibody, Cxcl1 antibody, Cxcl12 antibody, cxcl12.L antibody, cxcl12a antibody
    Background
    SDF1 alpha and 1 beta are small cytokines that belong to the intercrine family, members of which activate leukocytes and are often induced by proinflammatory stimuli such as lipopolysaccharide, TNF or IL1. SDF1 alpha has been shown to be chemotactic for lymphocytes and is recently reported to be a ligand for CXCR4 (LESTR/fusin), a co-receptor for HIV1 entry into T cells. SDF-1 binding to CXCR4 inhibits HIV1 entry.Synonyms: C-X-C motif chemokine 12, IRH, Intercrine reduced in hepatomas, PBSF, Pre-B cell growth-stimulating factor, SDF1A, SDF1B, Stromal cell-derived factor 1, hIRH
    Gene ID
    6387
    NCBI Accession
    NP_000600
    UniProt
    P48061
    Pathways
    Regulation of Cell Size, CXCR4-mediated Signaling Events, Negative Regulation of intrinsic apoptotic Signaling
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