SLC4A11 antibody (C-Term)

Catalog No. ABIN967035

Product Details anti-SLC4A11 Antibody

Target: SLC4A11 (Solute Carrier Family 4, Sodium Borate Transporter, Member 11 (SLC4A11))

Binding Specificity: C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC4A11 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human SLC4A11 (Sodium bicarbonate transporter-like protein 11)

Application Details

Restrictions: For Research Use only

Handling

Storage: 4 °C

References for anti-SLC4A11 antibody (ABIN967035)

Vithana, Morgan, Ramprasad, Tan, Yong, Venkataraman, Venkatraman, Yam, Nagasamy, Law, Rajagopal, Pang, Kumaramanickevel, Casey, Aung: "SLC4A11 mutations in Fuchs endothelial corneal dystrophy." in: Human molecular genetics, Vol. 17, Issue 5, pp. 656-66, (2008) (PubMed).

Jiao, Sultana, Garg, Ramamurthy, Vemuganti, Gangopadhyay, Hejtmancik, Kannabiran: "Autosomal recessive corneal endothelial dystrophy (CHED2) is associated with mutations in SLC4A11." in: Journal of medical genetics, Vol. 44, Issue 1, pp. 64-8, (2007) (PubMed).

Desir, Moya, Reish, Van Regemorter, Deconinck, David, Meire, Abramowicz: "Borate transporter SLC4A11 mutations cause both Harboyan syndrome and non-syndromic corneal endothelial dystrophy." in: Journal of medical genetics, Vol. 44, Issue 5, pp. 322-6, (2007) (PubMed).

Vithana, Morgan, Sundaresan, Ebenezer, Tan, Mohamed, Anand, Khine, Venkataraman, Yong, Salto-Tellez, Venkatraman, Guo, Hemadevi, Srinivasan, Prajna, Khine, Casey, Inglehearn, Aung: "Mutations in sodium-borate cotransporter SLC4A11 cause recessive congenital hereditary endothelial dystrophy (CHED2)." in: Nature genetics, Vol. 38, Issue 7, pp. 755-7, (2006) (PubMed).

Park, Li, Shcheynikov, Zeng, Muallem: "NaBC1 is a ubiquitous electrogenic Na+ -coupled borate transporter essential for cellular boron homeostasis and cell growth and proliferation." in: Molecular cell, Vol. 16, Issue 3, pp. 331-41, (2004) (PubMed).

Parker, Ourmozdi, Tanner: "Human BTR1, a new bicarbonate transporter superfamily member and human AE4 from kidney." in: Biochemical and biophysical research communications, Vol. 282, Issue 5, pp. 1103-9, (2001) (PubMed).

Target Details for SLC4A11

Target: SLC4A11 (Solute Carrier Family 4, Sodium Borate Transporter, Member 11 (SLC4A11))

Alternative Name: SLC4A11 (SLC4A11 Products)

Synonyms: NaBC1 antibody, si:dkey-12j14.4 antibody, AI503023 antibody, BTR1 antibody, CDPD1 antibody, CHED2 antibody, NABC1 antibody, dJ794I6.2 antibody, solute carrier family 4 member 11 antibody, solute carrier family 4 member 11 L homeolog antibody, solute carrier family 4, sodium borate transporter, member 11 antibody, solute carrier family 4, sodium bicarbonate transporter-like, member 11 antibody, Slc4a11 antibody, SLC4A11 antibody, slc4a11.L antibody, slc4a11 antibody

Background: SLC4A11 (Sodium bicarbonate transporter-like protein 11) involved in borate homeostasis. In the absence of borate, it functions as a Na(+) and OH(-)(H(+)) channel. In the presence of borate functions as an electrogenic Na(+) coupled borate cotransporter. SLC4A11 (Sodium bicarbonate transporter-like protein 11) is a multi-pass membrane protein. SLC4A11 is highly expressed in kidney, testis, salivary gland, thyroid, trachea and corneal endothelium. Defects in SLC4A11 are the cause of corneal dystrophy and perceptive deafness (CDPD), also known as corneal dystrophy and sensorineural deafness or Harboyan syndrome. CDPD consists of congenital corneal endothelial dystrophy and progressive perceptive deafness. Inheritance is autosomal recessive. Defects in SLC4A11 are the cause of corneal endothelial dystrophy type 2 (CHED2) [MIM:217700], also known as congenital hereditary endothelial dystrophy of cornea. This bilateral corneal dystrophy is characterized by corneal opacification and nystagmus. Inheritance is autosomal recessive.

Pathways: Proton Transport