MAK antibody (C-Term)

Catalog No. ABIN1881520

Product Details anti-MAK Antibody

Target: MAK (Male Germ Cell-Associated Kinase (MAK))

Binding Specificity: AA 595-623, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAK antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: M, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MAK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 595-623 amino acids from the C-terminal region of human MAK.

Clone: RB42425

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-MAK antibody (ABIN1881520)

Ma, Xia, Desai, Boucher, Guan, Shih, Shi, deVere White, Chen, Tepper, Kung: "Male germ cell-associated kinase, a male-specific kinase regulated by androgen, is a coactivator of androgen receptor in prostate cancer cells." in: Cancer research, Vol. 66, Issue 17, pp. 8439-47, (2006) (PubMed).

Fu, Larson, Chitta, Parker, Turk, Lawrence, Kaldis, Galaktionov, Cohn, Shabanowitz, Hunt, Sturgill: "Identification of yin-yang regulators and a phosphorylation consensus for male germ cell-associated kinase (MAK)-related kinase." in: Molecular and cellular biology, Vol. 26, Issue 22, pp. 8639-54, (2006) (PubMed).

Mungall, Palmer, Sims, Edwards, Ashurst, Wilming, Jones, Horton, Hunt, Scott, Gilbert, Clamp, Bethel, Milne, Ainscough, Almeida, Ambrose, Andrews, Ashwell, Babbage, Bagguley, Bailey, Banerjee, Barker et al.: "The DNA sequence and analysis of human chromosome 6. ..." in: Nature, Vol. 425, Issue 6960, pp. 805-11, (2003) (PubMed).

Xia, Robinson, Ma, Chen, Wu, Qiu, Kung: "Identification of human male germ cell-associated kinase, a kinase transcriptionally activated by androgen in prostate cancer cells." in: The Journal of biological chemistry, Vol. 277, Issue 38, pp. 35422-33, (2002) (PubMed).

Woodle, Newman, Cohen: "Sterically stabilized liposomes: physical and biological properties." in: Journal of drug targeting, Vol. 2, Issue 5, pp. 397-403, (1995) (PubMed).

Target Details for MAK

Target: MAK (Male Germ Cell-Associated Kinase (MAK))

Alternative Name: MAK (MAK Products)

Synonyms: RP62 antibody, dJ417M14.2 antibody, A930010O05Rik antibody, Ick antibody, fj04c02 antibody, wu:fj04c02 antibody, zgc:56603 antibody, rp62 antibody, xmak antibody, MGC82717 antibody, MGC146434 antibody, male germ cell associated kinase antibody, male germ cell-associated kinase antibody, male germ cell associated kinase L homeolog antibody, MAK antibody, Mak antibody, mak antibody, mak.L antibody

Background: The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. It is expressed almost exclusively in the testis, primarily in germ cells. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. There is, however, a study of the mouse homolog that has identified high levels of expression in developing sensory epithelia so its function may be more generalized.

Molecular Weight: 70581

NCBI Accession: NP_001229314, NP_001229886, NP_005897

UniProt: P20794