PRPS1,PRPS2,PRPS3 (AA 79-109), (N-Term) antibody

Catalog No. ABIN391076

Product Details

Target: PRPS1,PRPS2,PRPS3

Binding Specificity: AA 79-109, N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: B, Pr, Rat, X

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This PRPS1/PRPS2/PRPS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-109 amino acids from the N-terminal region of human PRPS1/PRPS2/PRPS3.

Clone: RB5438

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References

Funes, Quintero, Henderson, Martinez, Qureshi, Westwood, Clements, Bourboulia, Pedley, Moncada, Boshoff: "Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 15, pp. 6223-8, (2007) (PubMed).

Target Details

Target: PRPS1,PRPS2,PRPS3

Alternative Name: PRPS1/PRPS2/PRPS3

Background: Phosphoribosylpyrophosphate synthetase (PRPS, EC 2.7.6.1) catalyzes the phosphoribosylation of ribose 5-phosphate to 5-phosphoribosyl-1-pyrophosphate, which is necessary for the de novo and salvage pathways of purine, pyrimidine, and pyridine biosynthesis. By PCR of human lymphoblast mRNA using primers based on the cDNA sequence of rat PRS I (Prps1), Roessler et al. (1990) isolated a partial human PRPS1 cDNA. They used this partial cDNA to screen lymphoblast cDNA libraries and isolated additional cDNAs corresponding to the entire PRPS1 coding region. The deduced PRPS1 protein has 318 amino acids.

Molecular Weight: 34834

Gene ID: 5631

NCBI Accession: NP_001191331, NP_002755

UniProt: P60891