Progesterone Receptor antibody (AA 730-871)

Catalog No. ABIN969352

Product Details anti-Progesterone Receptor Antibody

Target: Progesterone Receptor (PGR)

Binding Specificity: AA 730-871

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Progesterone Receptor antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: purified

Immunogen: Purified recombinant fragment of PGR (aa730-871) expressed in E. coli.

Clone: 8A11H1

Isotype: IgG1

Application Details

Application Notes: ELISA: 1:10000, WB: 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

References for anti-Progesterone Receptor antibody (ABIN969352)

LEplattenier, Lai, van den Ham, Mol, van Sluijs, Teske: "Regulation of COX-2 expression in canine prostate carcinoma: increased COX-2 expression is not related to inflammation." in: Journal of veterinary internal medicine / American College of Veterinary Internal Medicine, Vol. 21, Issue 4, pp. 776-82, (2007) (PubMed).

Yin, Lin, Cheng, Marsh, Utsunomiya, Ishikawa, Xue, Reierstad, Innes, Thung, Kim, Xu, Bulun: "Progesterone receptor regulates Bcl-2 gene expression through direct binding to its promoter region in uterine leiomyoma cells." in: The Journal of clinical endocrinology and metabolism, Vol. 92, Issue 11, pp. 4459-66, (2007) (PubMed).

Saito, Ito, Nagase, Suzuki, Akahira, Okamura, Yaegashi, Sasano: "Progesterone receptor isoforms as a prognostic marker in human endometrial carcinoma." in: Cancer science, Vol. 97, Issue 12, pp. 1308-14, (2006) (PubMed).

Tung, Abdel-Hafiz, Shen, Harvell, Nitao, Richer, Sartorius, Takimoto, Horwitz: "Progesterone receptors (PR)-B and -A regulate transcription by different mechanisms: AF-3 exerts regulatory control over coactivator binding to PR-B." in: Molecular endocrinology (Baltimore, Md.), Vol. 20, Issue 11, pp. 2656-70, (2006) (PubMed).

Buser, Gass-Handel, Wyszomierski, Doppler, Leonhardt, Schaack, Rosen, Watkin, Anderson, Edwards: "Progesterone receptor repression of prolactin/signal transducer and activator of transcription 5-mediated transcription of the beta-casein gene in mammary epithelial cells." in: Molecular endocrinology (Baltimore, Md.), Vol. 21, Issue 1, pp. 106-25, (2006) (PubMed).

Target Details for Progesterone Receptor

Target: Progesterone Receptor (PGR)

Alternative Name: PGR (PGR Products)

Synonyms: NR3C3 antibody, PR antibody, 9930019P03Rik antibody, BB114106 antibody, ENSMUSG00000074510 antibody, PR-A antibody, PR-B antibody, XPR-1 antibody, pgr antibody, xpr-2 antibody, LOC443444 antibody, PGR antibody, pg antibody, pr antibody, gb:dq017620 antibody, progesterone receptor antibody, progesterone receptor L homeolog antibody, PGR antibody, Pgr antibody, pgr.L antibody, pgr antibody

Background:

Description: PGR: progesterone receptor. This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform A only, and mediate their own response genes and physiologic effects with little overlap. The location of transcription initiation for isoform B has not been clearly determined.

Aliases: PR, NR3C3, PGR

Gene ID: 5241

HGNC: 5241

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Smooth Muscle Cell Migration