SUPV3L1 antibody (N-Term)

Catalog No. ABIN1881857

Product Details anti-SUPV3L1 Antibody

Target: SUPV3L1 (Suppressor of Var1, 3-Like 1 (SUPV3L1))

Binding Specificity: AA 93-121, N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SUPV3L1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SUPV3L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 93-121 amino acids from the N-terminal region of human SUPV3L1.

Clone: RB24555

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-SUPV3L1 antibody (ABIN1881857)

Szczesny, Borowski, Brzezniak, Dmochowska, Gewartowski, Bartnik, Stepien: "Human mitochondrial RNA turnover caught in flagranti: involvement of hSuv3p helicase in RNA surveillance." in: Nucleic acids research, Vol. 38, Issue 1, pp. 279-98, (2010) (PubMed).

Wang, Shu, Lieser, Chen, Lee: "Human mitochondrial SUV3 and polynucleotide phosphorylase form a 330-kDa heteropentamer to cooperatively degrade double-stranded RNA with a 3'-to-5' directionality." in: The Journal of biological chemistry, Vol. 284, Issue 31, pp. 20812-21, (2009) (PubMed).

Khidr, Wu, Davila, Procaccio, Wallace, Lee: "Role of SUV3 helicase in maintaining mitochondrial homeostasis in human cells." in: The Journal of biological chemistry, Vol. 283, Issue 40, pp. 27064-73, (2008) (PubMed).

Bogenhagen, Rousseau, Burke: "The layered structure of human mitochondrial DNA nucleoids." in: The Journal of biological chemistry, Vol. 283, Issue 6, pp. 3665-75, (2008) (PubMed).

Pereira, Mason, Szczesny, Maddukuri, Dziwura, Jedrzejczak, Paul, Wojcik, Dybczynska, Tudek, Bartnik, Klysik, Bohr, Stepien: "Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality." in: Mechanisms of ageing and development, Vol. 128, Issue 11-12, pp. 609-17, (2007) (PubMed).

Target Details for SUPV3L1

Target: SUPV3L1 (Suppressor of Var1, 3-Like 1 (SUPV3L1))

Alternative Name: SUPV3L1 (SUPV3L1 Products)

Background: SUV3L1 is an ATPase and DNA/RNA helicase able to unwind DNA/DNA, DNA/RNA and RNA/RNA duplexes in the 5'-3' direction. It may protect cells from apoptosis.

Molecular Weight: 87991

NCBI Accession: NP_003162

UniProt: Q8IYB8