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PCCA antibody (N-Term)

PCCA Reactivity: Human, Mouse, Rat, Zebrafish (Danio rerio), Cow, Horse, Dog, Pig, Rabbit WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2777736
  • Target See all PCCA Antibodies
    PCCA (Propionyl CoA Carboxylase, alpha Polypeptide (PCCA))
    Binding Specificity
    • 7
    • 7
    • 6
    • 6
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 31
    • 7
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Zebrafish (Danio rerio), Cow, Horse, Dog, Pig, Rabbit
    Host
    • 30
    • 2
    Rabbit
    Clonality
    • 32
    Polyclonal
    Conjugate
    • 18
    • 4
    • 3
    • 3
    • 2
    • 2
    This PCCA antibody is un-conjugated
    Application
    • 28
    • 19
    • 18
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    LYYSRQCLMV SRNLGSVGYD PNEKTFDKIL VANRGEIACR VIRTCKKMGI
    Predicted Reactivity
    Cow: 86%, Dog: 86%, Horse: 83%, Human: 100%, Mouse: 77%, Pig: 86%, Rabbit: 86%, Rat: 86%, Zebrafish: 75%
    Characteristics
    This is a rabbit polyclonal antibody against PCCA. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human PCCA
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    Discover our top product PCCA Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 728 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Rincón, Aguado, Desviat, Sánchez-Alcudia, Ugarte, Pérez: "Propionic and methylmalonic acidemia: antisense therapeutics for intronic variations causing aberrantly spliced messenger RNA." in: American journal of human genetics, Vol. 81, Issue 6, pp. 1262-70, (2011) (PubMed).

  • Target
    PCCA (Propionyl CoA Carboxylase, alpha Polypeptide (PCCA))
    Alternative Name
    PCCA (PCCA Products)
    Synonyms
    pcca antibody, zgc:66359 antibody, C79630 antibody, wu:fb92g02 antibody, zgc:100925 antibody, propionyl-CoA carboxylase alpha subunit antibody, propionyl-COA carboxylase alpha chain, mitochondrial antibody, propionyl-CoA carboxylase alpha chain antibody, zinc finger CCCH-type containing 13 antibody, propionyl-Coenzyme A carboxylase, alpha polypeptide antibody, propionyl CoA carboxylase, alpha polypeptide antibody, propionyl-CoA carboxylase alpha subunit L homeolog antibody, PCCA antibody, Pcca antibody, BMEI0800 antibody, pccA antibody, NRI_0781 antibody, zc3h13 antibody, pcca antibody, pcca.L antibody
    Background
    PCCA is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA is the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia.The protein encoded by this gene is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA encodes the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia. Two transcript variants encoding different isoforms have been found for this gene.
    Alias Symbols: -
    Protein Interaction Partner: HUWE1, PARK2, IFIT1, UBE2N, UBC, EBNA-LP, PCCB,
    Protein Size: 728
    Molecular Weight
    75 kDa
    Gene ID
    5095
    NCBI Accession
    NM_000282, NP_000273
    UniProt
    Q8WXQ7
    Pathways
    Monocarboxylic Acid Catabolic Process
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