Dvl-B (C-Term) antibody

Catalog No. ABIN966016

Product Details

Target: Dvl-B

Binding Specificity: C-Term

Reactivity: Freshwater Flatworm (Schmidtea mediterranea)

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC)

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of Freshwater Flatworms Schmidtea mediterranea Dvl-b (Dishevelled-like protein)

Application Details

Restrictions: For Research Use only

Handling

Storage: 4 °C

References

Gurley, Rink, Sánchez Alvarado: "Beta-catenin defines head versus tail identity during planarian regeneration and homeostasis." in: Science (New York, N.Y.), Vol. 319, Issue 5861, pp. 323-7, (2008) (PubMed).

Target Details

Target: Dvl-B

Background: Dvl-b (Dishevelled-like protein) contains PDZ_signaling domain and DEP_dishevelled domain. PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. It may be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-Cterminal). DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway.