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SENP1 antibody (AA 262-289)

SENP1 Reactivity: Mouse WB Host: Rabbit Polyclonal RB40856 unconjugated
Catalog No. ABIN1881788
  • Target See all SENP1 Antibodies
    SENP1 (SUMO1/sentrin Specific Peptidase 1 (SENP1))
    Binding Specificity
    • 11
    • 9
    • 8
    • 8
    • 6
    • 6
    • 6
    • 6
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 262-289
    Reactivity
    • 67
    • 21
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Mouse
    Host
    • 77
    • 2
    Rabbit
    Clonality
    • 70
    • 9
    Polyclonal
    Conjugate
    • 32
    • 8
    • 8
    • 7
    • 6
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This SENP1 antibody is un-conjugated
    Application
    • 60
    • 45
    • 23
    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This Mouse Senp1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 262-289 amino acids from the Central region of mouse Senp1.
    Clone
    RB40856
    Isotype
    Ig Fraction
    Top Product
    Discover our top product SENP1 Primary Antibody
  • Application Notes
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Bawa-Khalfe, Cheng, Lin, Ittmann, Yeh: "SENP1 induces prostatic intraepithelial neoplasia through multiple mechanisms." in: The Journal of biological chemistry, Vol. 285, Issue 33, pp. 25859-66, (2010) (PubMed).

    Yu, Ji, Zhang, Renda, He, Lin, Cheng, Chen, Krause, Min: "SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis." in: The Journal of experimental medicine, Vol. 207, Issue 6, pp. 1183-95, (2010) (PubMed).

    Sharma, Murillas, Zhang, Kuehn: "N4BP1 is a newly identified nucleolar protein that undergoes SUMO-regulated polyubiquitylation and proteasomal turnover at promyelocytic leukemia nuclear bodies." in: Journal of cell science, Vol. 123, Issue Pt 8, pp. 1227-34, (2010) (PubMed).

    Li, Luo, Yu, Lin, Luo, Zhang, He, Kim, Kim, Tang, Min: "SENP1 mediates TNF-induced desumoylation and cytoplasmic translocation of HIPK1 to enhance ASK1-dependent apoptosis." in: Cell death and differentiation, Vol. 15, Issue 4, pp. 739-50, (2008) (PubMed).

    Cheng, Kang, Zhang, Yeh: "SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia." in: Cell, Vol. 131, Issue 3, pp. 584-95, (2007) (PubMed).

  • Target
    SENP1 (SUMO1/sentrin Specific Peptidase 1 (SENP1))
    Alternative Name
    Senp1 (SENP1 Products)
    Synonyms
    SuPr-2 antibody, 2310046A20Rik antibody, D15Ertd528e antibody, E330036L07Rik antibody, suPr-2 antibody, senp1 antibody, senp1a antibody, xsenp1 antibody, SENP1 antibody, Senp1 antibody, senp1b antibody, SUMO1/sentrin specific peptidase 1 antibody, SUMO1/sentrin specific peptidase 1 S homeolog antibody, sentrin/SUMO-specific protease 1 antibody, SUMO1/sentrin specific peptidase 1 L homeolog antibody, SENP1 antibody, Senp1 antibody, senp1.S antibody, senp1.L antibody, senp1 antibody
    Background
    Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression activity.
    Molecular Weight
    72511
    NCBI Accession
    NP_659100
    UniProt
    P59110
    Pathways
    Positive Regulation of Endopeptidase Activity
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