LGMN antibody (N-Term)

Catalog No. ABIN1881495

Product Details anti-LGMN Antibody

Target: LGMN (Legumain (LGMN))

Binding Specificity: AA 83-112, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LGMN antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: Pr

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This LGMN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 83-112 amino acids from the N-terminal region of human LGMN.

Clone: RB41868

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-LGMN antibody (ABIN1881495)

Clerin, Shih, Deng, Hebert, Resmini, Shields, Feldman, Winkler, Albert, Maganti, Wong, Paulsen, Keith, Vlasuk, Pittman: "Expression of the cysteine protease legumain in vascular lesions and functional implications in atherogenesis." in: Atherosclerosis, Vol. 201, Issue 1, pp. 53-66, (2009) (PubMed).

Liu, Jang, Liu, Cheng, Peng, Yepes, Li, Matthews, Watts, Asano, Hara-Nishimura, Luo, Ye: "Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase." in: Molecular cell, Vol. 29, Issue 6, pp. 665-78, (2008) (PubMed).

Oh, Yang, Hahn, Kim, Byun, Jeon, Kim, Song, Noh, Kim, Yoo, Kim, Kim: "Transcriptome analysis of human gastric cancer." in: Mammalian genome : official journal of the International Mammalian Genome Society, Vol. 16, Issue 12, pp. 942-54, (2005) (PubMed).

Target Details for LGMN

Target: LGMN (Legumain (LGMN))

Alternative Name: LGMN (LGMN Products)

Synonyms: AEP antibody, LGMN1 antibody, PRSC1 antibody, AI746452 antibody, AU022324 antibody, Prsc1 antibody, MGC64351 antibody, cb173 antibody, cb460 antibody, sb:cb173 antibody, zgc:76953 antibody, wu:fa98g05 antibody, wu:fj92g08 antibody, lgmn antibody, MGC88980 antibody, DELTA VACUOLAR PROCESSING ENZYME antibody, DELTAVPE antibody, delta vacuolar processing enzyme antibody, legumain antibody, legumain L homeolog antibody, delta vacuolar processing enzyme antibody, Legumain antibody, LGMN antibody, Lgmn antibody, lgmn.L antibody, lgmn antibody, DELTA-VPE antibody, MBOO_RS07785 antibody, Odosp_3582 antibody, LOC569153 antibody

Background: This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform.

Molecular Weight: 49411

NCBI Accession: NP_001008530, NP_005597

UniProt: Q99538

Pathways: Metabolism of Steroid Hormones and Vitamin D, Activation of Innate immune Response, Toll-Like Receptors Cascades