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PDE4B antibody (Middle Region)

PDE4B Reactivity: Human, Mouse, Rat, Guinea Pig, Horse, Cow, Dog, Pig, Rabbit WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2786603
  • Target See all PDE4B Antibodies
    PDE4B (phosphodiesterase 4B, cAMP-Specific (PDE4B))
    Binding Specificity
    • 7
    • 7
    • 6
    • 6
    • 5
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 36
    • 12
    • 11
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Guinea Pig, Horse, Cow, Dog, Pig, Rabbit
    Host
    • 35
    • 2
    • 1
    Rabbit
    Clonality
    • 36
    • 2
    Polyclonal
    Conjugate
    • 20
    • 6
    • 5
    • 3
    • 2
    • 2
    This PDE4B antibody is un-conjugated
    Application
    • 32
    • 23
    • 14
    • 12
    • 9
    • 8
    • 8
    • 6
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    QDILDTLEDN RNWYQSMIPQ SPSPPLDEQN RDCQGLMEKF QFELTLDEED
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 83%, Horse: 100%, Human: 100%, Mouse: 86%, Pig: 100%, Rabbit: 93%, Rat: 93%
    Characteristics
    This is a rabbit polyclonal antibody against PDE4B. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human PDE4B
    Top Product
    Discover our top product PDE4B Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 564 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Fatemi, King, Reutiman, Folsom, Laurence, Lee, Fan, Paciga, Conti, Menniti: "PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia." in: Schizophrenia research, Vol. 101, Issue 1-3, pp. 36-49, (2008) (PubMed).

  • Target
    PDE4B (phosphodiesterase 4B, cAMP-Specific (PDE4B))
    Alternative Name
    PDE4B (PDE4B Products)
    Synonyms
    dpde4 antibody, pde4b5 antibody, pdeivb antibody, Dpde4 antibody, R74983 antibody, dunce antibody, PDE4/IVb antibody, Pde4B1 antibody, Pde4B2 antibody, Pde4B3 antibody, Pde4B4 antibody, DPDE4 antibody, PDE4B5 antibody, PDEIVB antibody, phosphodiesterase 4B antibody, phosphodiesterase 4B, cAMP specific antibody, phosphodiesterase 4B S homeolog antibody, pde4b antibody, PDE4B antibody, Pde4b antibody, pde4b.S antibody
    Background
    The specific function of this protein remains unknown.This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
    Alias Symbols: DKFZp686F2182, DPDE4, MGC126529, PDE4B5, PDEIVB
    Protein Interaction Partner: MAGEA11, RCBTB2, APOA1, ALB, PAFAH1B1, UBC, DISC1, PRKACA,
    Protein Size: 564
    Molecular Weight
    64 kDa
    Gene ID
    5142
    NCBI Accession
    NM_001037339, NP_001032416
    UniProt
    Q5TEK5
    Pathways
    Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Myometrial Relaxation and Contraction
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