Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

ISCU antibody (C-Term)

ISCU Reactivity: Human, Mouse WB Host: Rabbit Polyclonal RB35591 unconjugated
Catalog No. ABIN1881467
  • Target See all ISCU Antibodies
    ISCU (Iron-sulfur cluster assembly enzyme ISCU, mitochondrial (ISCU))
    Binding Specificity
    • 13
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 138-167, C-Term
    Reactivity
    • 31
    • 13
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 27
    • 4
    Rabbit
    Clonality
    • 27
    • 3
    Polyclonal
    Conjugate
    • 17
    • 4
    • 3
    • 3
    • 2
    • 2
    This ISCU antibody is un-conjugated
    Application
    • 25
    • 22
    • 5
    • 4
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This ISCU antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-167 amino acids from the C-terminal region of human ISCU.
    Clone
    RB35591
    Isotype
    Ig Fraction
    Top Product
    Discover our top product ISCU Primary Antibody
  • Application Notes
    WB: 1:1000. WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Okerlund, Kivimäe, Tong, Peng, Ullian, Cheyette: "Dact1 is a postsynaptic protein required for dendrite, spine, and excitatory synapse development in the mouse forebrain." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 12, pp. 4362-8, (2010) (PubMed).

    Chan, Zhang, Hemann, Mahoney, Zweier, Loscalzo: "MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2." in: Cell metabolism, Vol. 10, Issue 4, pp. 273-84, (2009) (PubMed).

    Kollberg, Tulinius, Melberg, Darin, Andersen, Holmgren, Oldfors, Holme: "Clinical manifestation and a new ISCU mutation in iron-sulphur cluster deficiency myopathy." in: Brain : a journal of neurology, Vol. 132, Issue Pt 8, pp. 2170-9, (2009) (PubMed).

    Huang, Dizin, Cowan: "Mapping iron binding sites on human frataxin: implications for cluster assembly on the ISU Fe-S cluster scaffold protein." in: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, Vol. 13, Issue 5, pp. 825-36, (2008) (PubMed).

    Mochel, Knight, Tong, Hernandez, Ayyad, Taivassalo, Andersen, Singleton, Rouault, Fischbeck, Haller: "Splice mutation in the iron-sulfur cluster scaffold protein ISCU causes myopathy with exercise intolerance." in: American journal of human genetics, Vol. 82, Issue 3, pp. 652-60, (2008) (PubMed).

  • Target
    ISCU (Iron-sulfur cluster assembly enzyme ISCU, mitochondrial (ISCU))
    Alternative Name
    ISCU (ISCU Products)
    Synonyms
    nifun antibody, zC191D15.3 antibody, si:ch211-191d15.3 antibody, 2310020H20Rik antibody, HML antibody, ISU2 antibody, NIFU antibody, NIFUN antibody, hnifU antibody, RGD1309562 antibody, AA407971 antibody, Nifu antibody, Nifun antibody, iron-sulfur cluster assembly enzyme ISCU, mitochondrial antibody, iron-sulfur cluster assembly enzyme antibody, iron-sulfur cluster assembly enzyme a antibody, LOC409130 antibody, ISCU antibody, iscua antibody, Iscu antibody
    Background
    Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. They contain sulfur and iron, and are created via several steps that include cysteine desulfurases, iron donors, chaperones, and scaffold proteins. This gene encodes the two isomeric forms, ISCU1 and ISCU2, of the Fe-S cluster scaffold protein. Mutations in this gene have been found in patients with myopathy with severe exercise intolerance and myoglobinuria.
    Molecular Weight
    17999
    NCBI Accession
    NP_055116, NP_998760
    UniProt
    Q9H1K1
You are here:
Support