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MAVS antibody (AA 160-450)

MAVS Reactivity: Human WB, IHC, IP, ICC Host: Mouse Monoclonal Adri-1 unconjugated
Catalog No. ABIN1169132
  • Target See all MAVS Antibodies
    MAVS (Mitochondrial Antiviral Signaling Protein (MAVS))
    Binding Specificity
    • 15
    • 13
    • 9
    • 8
    • 8
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 160-450
    Reactivity
    • 48
    • 38
    • 4
    • 2
    • 1
    Human
    Host
    • 70
    • 6
    Mouse
    Clonality
    • 72
    • 4
    Monoclonal
    Conjugate
    • 34
    • 6
    • 6
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This MAVS antibody is un-conjugated
    Application
    • 68
    • 37
    • 13
    • 13
    • 10
    • 9
    • 8
    • 8
    • 5
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC)
    Specificity
    Recognizes human Cardif.
    Cross-Reactivity
    Human
    Purification
    Purified from concentrated hybridoma tissue culture supernatant.
    Purity
    >95 % (SDS-PAGE)
    Immunogen
    Recombinant human Cardif (aa 160-450).
    Clone
    Adri-1
    Isotype
    IgG2b
    Top Product
    Discover our top product MAVS Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    In PBS containing 10 % glycerol and 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 1 year after receipt when stored at -20°C.
    Expiry Date
    12 months
  • Morikawa, Gouttenoire, Hernandez, Dao Thi, Tran, Lange, Dill, Heim, Donzé, Penin, Quadroni, Moradpour: "Quantitative proteomics identifies the membrane-associated peroxidase GPx8 as a cellular substrate of the hepatitis C virus NS3-4A protease." in: Hepatology (Baltimore, Md.), Vol. 59, Issue 2, pp. 423-33, (2014) (PubMed).

    Bellecave, Sarasin-Filipowicz, Donzé, Kennel, Gouttenoire, Meylan, Terracciano, Tschopp, Sarrazin, Berg, Moradpour, Heim: "Cleavage of mitochondrial antiviral signaling protein in the liver of patients with chronic hepatitis C correlates with a reduced activation of the endogenous interferon system." in: Hepatology (Baltimore, Md.), Vol. 51, Issue 4, pp. 1127-36, (2010) (PubMed).

    Michallet, Meylan, Ermolaeva, Vazquez, Rebsamen, Curran, Poeck, Bscheider, Hartmann, König, Kalinke, Pasparakis, Tschopp: "TRADD protein is an essential component of the RIG-like helicase antiviral pathway." in: Immunity, Vol. 28, Issue 5, pp. 651-61, (2008) (PubMed).

  • Target
    MAVS (Mitochondrial Antiviral Signaling Protein (MAVS))
    Alternative Name
    Cardif (MAVS Products)
    Synonyms
    CARDIF antibody, IPS-1 antibody, IPS1 antibody, VISA antibody, D430028G21Rik antibody, Visa antibody, cardif antibody, wu:fj20d04 antibody, zgc:158392 antibody, mitochondrial antiviral signaling protein antibody, MAVS antibody, Mavs antibody, mavs antibody
    Background
    RIG-I (retinoic acid-inducible gene I, Ddx58) and MDA5 (melanoma differentiation-associated gene 5, also known as Ifih1 or Helicard) are proteins that sense viral replication intermediates, such as double-stranded RNA and triggers the host antiviral programs. These molecules signal the downstream activation of NF-kappaB and IFN regulatory factor (IRF) -3, which coordinately regulate the expression of type-I interferons. Cardif (also called VISA/IPS-1/MAVS) is a new CARD (caspase activation and recruitment domain)-containing adaptor protein that interacts with the CARD domain of RIG-I and MDA5, leading to the activation of NF-kappaB and IRF3. Cardif is located to the mitochondrial outer membrane. Removal of the mitochondrial-targeting domain of cardif abolishes its ability to induce IFNs. Cardif is cleaved and inactivated by NS3-4A, a serine protease from hepatitis C virus known to block interferon-beta production.
    UniProt
    Q7Z434
    Pathways
    Activation of Innate immune Response, Inositol Metabolic Process, Hepatitis C
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