CCDC6 antibody (N-Term)

Catalog No. ABIN1881146

Product Details anti-CCDC6 Antibody

Target: CCDC6 (Coiled-Coil Domain Containing 6 (CCDC6))

Binding Specificity: AA 54-82, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCDC6 antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CCDC6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 54-82 amino acids from the N-terminal region of human CCDC6.

Clone: RB40538

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-CCDC6 antibody (ABIN1881146)

Leone, Mansueto, Pierantoni, Tornincasa, Merolla, Cerrato, Santoro, Grieco, Scaloni, Celetti, Fusco: "CCDC6 represses CREB1 activity by recruiting histone deacetylase 1 and protein phosphatase 1." in: Oncogene, Vol. 29, Issue 30, pp. 4341-51, (2010) (PubMed).

Richardson, Gujral, Peng, Asa, Mulligan: "Transcript level modulates the inherent oncogenicity of RET/PTC oncoproteins." in: Cancer research, Vol. 69, Issue 11, pp. 4861-9, (2009) (PubMed).

Jazdzewski, Murray, Franssila, Jarzab, Schoenberg, de la Chapelle: "Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 20, pp. 7269-74, (2008) (PubMed).

Sugiyama, Masuda, Shinoda, Nakamura, Tomita, Ishihama: "Phosphopeptide enrichment by aliphatic hydroxy acid-modified metal oxide chromatography for nano-LC-MS/MS in proteomics applications." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 6, pp. 1103-9, (2007) (PubMed).

Target Details for CCDC6

Target: CCDC6 (Coiled-Coil Domain Containing 6 (CCDC6))

Alternative Name: CCDC6 (CCDC6 Products)

Background: This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.

Molecular Weight: 53291

NCBI Accession: NP_005427

UniProt: Q16204