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Zona Pellucida Glycoprotein 3 antibody (C-Term)

ZP3 Reactivity: Human, Rat, Cow, Horse, Rabbit WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2776494
  • Target See all Zona Pellucida Glycoprotein 3 (ZP3) Antibodies
    Zona Pellucida Glycoprotein 3 (ZP3)
    Binding Specificity
    • 8
    • 8
    • 6
    • 2
    • 1
    • 1
    C-Term
    Reactivity
    • 22
    • 3
    • 2
    • 1
    • 1
    • 1
    Human, Rat, Cow, Horse, Rabbit
    Host
    • 20
    • 2
    Rabbit
    Clonality
    • 22
    Polyclonal
    Conjugate
    • 12
    • 2
    • 2
    • 2
    • 2
    • 2
    This Zona Pellucida Glycoprotein 3 antibody is un-conjugated
    Application
    • 20
    • 14
    • 3
    • 1
    Western Blotting (WB)
    Sequence
    NKGDCGTPSH SRRQPHVMSQ WSRSASRNRR HVTEEADVTV GATDLPGQEW
    Predicted Reactivity
    Cow: 100%, Horse: 100%, Human: 100%, Rabbit: 100%, Rat: 90%
    Characteristics
    This is a rabbit polyclonal antibody against ZP3. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Protein A purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C terminal region of human ZP3
    Top Product
    Discover our top product ZP3 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 424 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Amorim, Moya, Donnez, Dolmans: "Morphometric characteristics of preantral and antral follicles and expression of factors involved in folliculogenesis in ovaries of adult baboons (Papio anubis)." in: Journal of assisted reproduction and genetics, Vol. 33, Issue 5, pp. 617-626, (2016) (PubMed).

    Törmälä, Jääskeläinen, Lakkakorpi, Liakka, Tapanainen, Vaskivuo: "Zona pellucida components are present in human fetal ovary before follicle formation." in: Molecular and cellular endocrinology, Vol. 289, Issue 1-2, pp. 10-5, (2008) (PubMed).

  • Target
    Zona Pellucida Glycoprotein 3 (ZP3)
    Alternative Name
    ZP3 (ZP3 Products)
    Synonyms
    ZP3A antibody, ZP3B antibody, ZPC antibody, Zp-3 antibody, zp3.2 antibody, Zp-3B antibody, zona pellucida glycoprotein 3 antibody, zona pellucida sperm-binding protein 3 antibody, ZP3 antibody, zp3 antibody, Zp3 antibody
    Background
    The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus, however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene
    Alias Symbols: ZPC, ZP3A, ZP3B, Zp-3
    Protein Interaction Partner: HECW2, OR2L13, SPACA3, MICALL1, MRPS16, PCDH17, UBAP2L, UBC, ENGASE, ACR, FURIN,
    Protein Size: 424
    Molecular Weight
    47 kDa
    Gene ID
    7784
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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