Kv2.2 antibody (N-Term)

Catalog No. ABIN1881474

Product Details anti-Kv2.2 Antibody

Target: Kv2.2 (KCNB2) (Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 2 (KCNB2))

Binding Specificity: AA 138-166, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Kv2.2 antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: B, M, Rb

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This KCNB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-166 amino acids from the N-terminal region of human KCNB2.

Clone: RB40837

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-Kv2.2 antibody (ABIN1881474)

Cirulli, Kasperaviciūte, Attix, Need, Ge, Gibson, Goldstein: "Common genetic variation and performance on standardized cognitive tests." in: European journal of human genetics : EJHG, Vol. 18, Issue 7, pp. 815-20, (2010) (PubMed).

Baranzini, Wang, Gibson, Galwey, Naegelin, Barkhof, Radue, Lindberg, Uitdehaag, Johnson, Angelakopoulou, Hall, Richardson, Prinjha, Gass, Geurts, Kragt, Sombekke, Vrenken, Qualley, Lincoln et al.: "Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis...." in: Human molecular genetics, Vol. 18, Issue 4, pp. 767-78, (2009) (PubMed).

Nyholt, LaForge, Kallela, Alakurtti, Anttila, Färkkilä, Hämaläinen, Kaprio, Kaunisto, Heath, Montgomery, Göbel, Todt, Ferrari, Launer, Frants, Terwindt, de Vries, Verschuren, Brand: "A high-density association screen of 155 ion transport genes for involvement with common migraine." in: Human molecular genetics, Vol. 17, Issue 21, pp. 3318-31, (2008) (PubMed).

Wu, Ma, Brown, Geisler, Li, Tzeng, Jia, Jurisica, Li: "Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening." in: Proteomics, Vol. 7, Issue 11, pp. 1775-85, (2007) (PubMed).

Hanna, Kruskal, Ezekowitz, Bloom, Collier: "Role of macrophage oxidative burst in the action of anthrax lethal toxin." in: Molecular medicine (Cambridge, Mass.), Vol. 1, Issue 1, pp. 7-18, (1996) (PubMed).

Target Details for Kv2.2

Target: Kv2.2 (KCNB2) (Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 2 (KCNB2))

Alternative Name: KCNB2 (KCNB2 Products)

Synonyms: KCNB2 antibody, si:ch211-193n21.1 antibody, Kv2.2 antibody, 9630047L19Rik antibody, BB130875 antibody, XShab12 antibody, kcnb2 antibody, KV2.2 antibody, potassium voltage-gated channel subfamily B member 2 antibody, potassium voltage-gated channel, Shab-related subfamily, member 2 antibody, potassium channel, voltage gated Shab related subfamily B, member 2 antibody, potassium voltage gated channel, Shab-related subfamily, member 2 antibody, potassium channel, voltage gated Shab related subfamily B, member 2 S homeolog antibody, KCNB2 antibody, kcnb2 antibody, LOC100051372 antibody, Kcnb2 antibody, kcnb2.S antibody

Background: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel. The gene is expressed in gastrointestinal smooth muscle cells.

Molecular Weight: 102563

NCBI Accession: NP_004761

UniProt: Q92953