Substance P Peptide

Catalog No. ABIN399822

Product Details

Target: Substance P

Purity: > 95 %

Application Details

Restrictions: For Research Use only

Handling

Storage: -20 °C

References

Susa, Mortensen, Williams: "Effects of cations on protein and peptide charging in electrospray ionization from aqueous solutions." in: Journal of the American Society for Mass Spectrometry, Vol. 25, Issue 6, pp. 918-27, (2014) (PubMed).

Lindenburg, Tempels, Tjaden, van der Greef, Hankemeier: "On-line large-volume electroextraction coupled to liquid chromatography-mass spectrometry to improve detection of peptides." in: Journal of chromatography. A, Vol. 1249, pp. 17-24, (2012) (PubMed).

Lindenburg, Seitzinger, Tempels, Tjaden, van der Greef, Hankemeier: "Online capillary liquid-liquid electroextraction of peptides as fast pre-concentration prior to LC-MS." in: Electrophoresis, Vol. 31, Issue 23-24, pp. 3903-12, (2010) (PubMed).

Carr, Torres, Koch, Reiter: "Investigation of the pruritogenic effects of histamine, serotonin, tryptase, substance P and interleukin-2 in healthy dogs." in: Veterinary dermatology, Vol. 20, Issue 2, pp. 105-10, (2009) (PubMed).

Target Details

Target: Substance P

Synonyms: Hs.2563 Peptide, NK2 Peptide, NKNA Peptide, NPK Peptide, TAC2 Peptide, PPTA3 Peptide, Ppt5fl Peptide, RATPPTA3 Peptide, TAC Peptide, 4930528L02Rik Peptide, NK-1 Peptide, NK1 Peptide, Nkna Peptide, PPT-A Peptide, PPTA Peptide, SP Peptide, PPT Peptide, beta-PPT-A Peptide, NKA Peptide, tachykinin precursor 1 Peptide, tachykinin, precursor 1 Peptide, tachykinin 1 Peptide, TAC1 Peptide, Tac1 Peptide

Background: Substance P is found in the gut and in the brain. It is responsible for a number of excitatory effects on both central and peripheral neurons. Substance P contracts smooth muscle, constricts bronchioles, and increases capillary permeability. When released from afferent nerves, Substance P causes a neurogenic inflammatory response, including mast cell degranulation. It's an NK-1 agonist, a potent vasodilator and hypotensive agent, it induces salivation, it's a putative neurotransmitter in sensory (pain) afferents.

CAS-No: 33507-63-0