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PIM3 antibody (C-Term)

PIM3 Reactivity: Human, Mouse WB, IHC (p) Host: Rabbit Polyclonal RB8591 unconjugated
Catalog No. ABIN391253
  • Target See all PIM3 Antibodies
    PIM3 (Pim-3 Oncogene (PIM3))
    Binding Specificity
    • 8
    • 6
    • 1
    • 1
    • 1
    • 1
    AA 259-288, C-Term
    Reactivity
    • 27
    • 11
    • 2
    Human, Mouse
    Host
    • 25
    • 2
    Rabbit
    Clonality
    • 25
    • 2
    Polyclonal
    Conjugate
    • 11
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PIM3 antibody is un-conjugated
    Application
    • 15
    • 15
    • 13
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Predicted Reactivity
    Rat
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This PIM3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 259-288 amino acids from the C-terminal region of human PIM3.
    Clone
    RB8591
    Isotype
    Ig Fraction
    Top Product
    Discover our top product PIM3 Primary Antibody
  • Application Notes
    WB: 1:1000. IHC-P: 1:10~50. IHC-P: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Ishikawa, Senba, Hashimoto, Imaizumi, Mori: "Expression and significance of Pim-3 kinase in adult T-cell leukemia." in: European journal of haematology, Vol. 99, Issue 6, pp. 495-504, (2018) (PubMed).

    Decker, Finter, Forde, Kissel, Schwaller, Mack, Kuhn, Gray, Follo, Jumaa, Burger, Zirlik, Pfeifer, Miduturu, Eibel, Veelken, Dierks: "PIM kinases are essential for chronic lymphocytic leukemia cell survival (PIM2/3) and CXCR4-mediated microenvironmental interactions (PIM1)." in: Molecular cancer therapeutics, Vol. 13, Issue 5, pp. 1231-45, (2014) (PubMed).

    Brault, Menter, Obermann, Knapp, Thommen, Schwaller, Tzankov: "PIM kinases are progression markers and emerging therapeutic targets in diffuse large B-cell lymphoma." in: British journal of cancer, Vol. 107, Issue 3, pp. 491-500, (2012) (PubMed).

    Chen, Redkar, Bearss, Wierda, Gandhi: "Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells." in: Blood, Vol. 114, Issue 19, pp. 4150-7, (2009) (PubMed).

    Cheng, Weidner-Glunde, Varjosalo, Rainio, Lehtonen, Schulz, Koskinen, Taipale, Ojala: "KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANA." in: PLoS pathogens, Vol. 5, Issue 3, pp. e1000324, (2009) (PubMed).

  • Target
    PIM3 (Pim-3 Oncogene (PIM3))
    Alternative Name
    PIM3 (PIM3 Products)
    Synonyms
    pim1-a antibody, pim-3 antibody, BC026639 antibody, Kid1 antibody, Serine/threonine-protein kinase Pim-3 antibody, Pim-3 proto-oncogene, serine/threonine kinase S homeolog antibody, Pim-3 proto-oncogene, serine/threonine kinase antibody, pim-3 oncogene antibody, proviral integration site 3 antibody, pim3 antibody, pim3.S antibody, PIM3 antibody, Pim3 antibody
    Background
    PIM3 is a memberof the Ser/Thr protein kinase family that may be involved in cell cycle progression and anti-apoptosis process. This protein has been implicated in proliferation of human hepatoma cell lines. PIM3 is widely expressed, with the exception of no expression observed in colon, thymus, and small intestine. PIM3 is expressed in human hepatoma cell lines but not in normal liver tissues.
    Molecular Weight
    35891
    Gene ID
    415116
    NCBI Accession
    NP_001001852
    UniProt
    Q86V86
    Pathways
    Negative Regulation of Hormone Secretion
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