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AGL antibody (C-Term)

AGL Reactivity: Human WB, IF Host: Rabbit Polyclonal RB4978 unconjugated
Catalog No. ABIN389030
  • Target See all AGL Antibodies
    AGL (Amylo-alpha-1, 6-Glucosidase, 4-alpha-Glucanotransferase (AGL))
    Binding Specificity
    • 7
    • 7
    • 7
    • 7
    • 4
    • 2
    • 1
    • 1
    AA 1479-1510, C-Term
    Reactivity
    • 39
    • 1
    Human
    Host
    • 37
    • 2
    Rabbit
    Clonality
    • 38
    • 1
    Polyclonal
    Conjugate
    • 15
    • 4
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This AGL antibody is un-conjugated
    Application
    • 23
    • 23
    • 22
    • 10
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This AGL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1479-1510 amino acids from the C-terminal region of human AGL.
    Clone
    RB4978
    Isotype
    Ig Fraction
  • Application Notes
    IF: 1:10~50. IF: 1:10~50. WB: 1:1000. WB: 1:8000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Guin, Ru, Agarwal, Ritterson Lew, Owens, Comi, Theodorescu: "Loss of glycogen debranching enzyme AGL drives bladder tumor growth via induction of hyaluronic acid synthesis." in: Clinical cancer research : an official journal of the American Association for Cancer Research, (2015) (PubMed).

    Liu, Zeng, Ma, Baba, Zheng, Liu, Wang: "Laforin-malin complex degrades polyglucosan bodies in concert with glycogen debranching enzyme and brain isoform glycogen phosphorylase." in: Molecular neurobiology, Vol. 49, Issue 2, pp. 645-57, (2014) (PubMed).

    Zhu, Shen, Zhu, Coorey, Nguyen, Barthelmes, Gillies: "Anti-retinal antibodies in patients with macular telangiectasia type 2." in: Investigative ophthalmology & visual science, Vol. 54, Issue 8, pp. 5675-83, (2013) (PubMed).

    DePaoli-Roach, Tagliabracci, Segvich, Meyer, Irimia, Roach: "Genetic depletion of the malin E3 ubiquitin ligase in mice leads to lafora bodies and the accumulation of insoluble laforin." in: The Journal of biological chemistry, Vol. 285, Issue 33, pp. 25372-81, (2010) (PubMed).

    Parker, Kong, Walsh, Salajegheh, Moghadaszadeh, Amato, Nazareno, Lin, Krastins, Sarracino, Beggs, Pinkus, Greenberg: "Fast-twitch sarcomeric and glycolytic enzyme protein loss in inclusion body myositis." in: Muscle & nerve, Vol. 39, Issue 6, pp. 739-53, (2009) (PubMed).

    Cheng, Zhang, Gentry, Worby, Dixon, Saltiel: "A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease." in: Genes & development, Vol. 21, Issue 19, pp. 2399-409, (2007) (PubMed).

  • Target
    AGL (Amylo-alpha-1, 6-Glucosidase, 4-alpha-Glucanotransferase (AGL))
    Alternative Name
    AGL (AGL Products)
    Synonyms
    DDBDRAFT_0219237 antibody, DDBDRAFT_0234114 antibody, DDB_0219237 antibody, DDB_0234114 antibody, GDE antibody, 1110061O17Rik antibody, 9430004C13Rik antibody, 9630046L06Rik antibody, AI850929 antibody, C77197 antibody, amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase antibody, glycogen debranching enzyme antibody, glycogen debranching protein antibody, amylo-1,6-glucosidase, 4-alpha-glucanotransferase antibody, AGL antibody, agl antibody, MMAH_RS03870 antibody, Agl antibody
    Background
    AGL is a glycogen debrancher enzyme which is involved in glycogen degradation. This enzyme has two independent catalytic activities which occur at different sites on the protein: a 4-alpha-glucotransferase activity and a amylo-1,6-glucosidase activity. Mutations in the AGL gene are associated with glycogen storage disease although a wide range of enzymatic and clinical variability occurs which may be due to tissue-specific alternative splicing.
    Molecular Weight
    174764
    Gene ID
    178
    NCBI Accession
    NP_000019, NP_000633, NP_000634, NP_000635, NP_000636, NP_000637
    UniProt
    P35573
    Pathways
    Cellular Glucan Metabolic Process
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