DAB2 antibody (C-Term)

Catalog No. ABIN1881248

Product Details anti-DAB2 Antibody

Target: DAB2 (Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2))

Binding Specificity: AA 624-650, C-Term

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DAB2 antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Mouse Dab2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 624-650 amino acids from the C-terminal region of mouse Dab2.

Clone: RB40861

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-DAB2 antibody (ABIN1881248)

Collaco, Jakab, Hegan, Mooseker, Ameen: "Alpha-AP-2 directs myosin VI-dependent endocytosis of cystic fibrosis transmembrane conductance regulator chloride channels in the intestine." in: The Journal of biological chemistry, Vol. 285, Issue 22, pp. 17177-87, (2010) (PubMed).

Chaudhury, Hussey, Ray, Jin, Fox, Howe: "TGF-beta-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI." in: Nature cell biology, Vol. 12, Issue 3, pp. 286-93, (2010) (PubMed).

Hasumi, Baba, Ajima, Hasumi, Valera, Klein, Haines, Merino, Hong, Yamaguchi, Schmidt, Linehan: "Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 44, pp. 18722-7, (2009) (PubMed).

Jain, Nguyen, Friedline, Malhotra, Brehm, Koyanagi, Bix, Cooper, Chambers, Kang: "Cutting edge: Dab2 is a FOXP3 target gene required for regulatory T cell function." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 7, pp. 4192-6, (2009) (PubMed).

Jiang, Luo, Howe: "Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions." in: Oncogene, Vol. 28, Issue 33, pp. 2999-3007, (2009) (PubMed).

Target Details for DAB2

Target: DAB2 (Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2))

Alternative Name: Dab2 (DAB2 Products)

Synonyms: DOC-2 antibody, DOC2 antibody, 5730435J12Rik antibody, AA960054 antibody, AI957090 antibody, D15Wsu122e antibody, D630005B22Rik antibody, Doc-2 antibody, Doc2 antibody, p96 antibody, DAB2, clathrin adaptor protein antibody, disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) antibody, Dab, mitogen-responsive phosphoprotein, homolog 2 antibody, disabled 2, mitogen-responsive phosphoprotein antibody, DAB2 antibody, dab2 antibody, Dab2 antibody

Background: Component of the CSF-1 signal transduction pathway.

Molecular Weight: 82312

NCBI Accession: NP_001008702, NP_001032994, NP_075607

UniProt: P98078

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process