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ASK1 antibody

MAP3K5 Reactivity: Human WB, ELISA, IHC, FACS, ICC Host: Mouse Monoclonal 2-00E-04 unconjugated
Catalog No. ABIN969273
  • Target See all ASK1 (MAP3K5) Antibodies
    ASK1 (MAP3K5) (Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5))
    Reactivity
    • 182
    • 100
    • 57
    • 18
    • 15
    • 8
    Human
    Host
    • 192
    • 7
    Mouse
    Clonality
    • 172
    • 27
    Monoclonal
    Conjugate
    • 81
    • 12
    • 12
    • 9
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 1
    This ASK1 antibody is un-conjugated
    Application
    • 158
    • 57
    • 39
    • 39
    • 37
    • 30
    • 28
    • 20
    • 11
    • 10
    • 7
    • 4
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)
    Purification
    purified
    Immunogen
    Purified recombinant fragment of human MAP3K5 expressed in E. coli.
    Clone
    2-00E-04
    Isotype
    IgG1
    Top Product
    Discover our top product MAP3K5 Primary Antibody
  • Application Notes
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    4°C, -20°C for long term storage
  • Widenmaier, Ao, Kim, Warnock, McIntosh et al.: "Suppression of p38 MAPK and JNK via Akt-mediated inhibition of apoptosis signal-regulating kinase 1 constitutes a core component of the beta-cell pro-survival effects of glucose-dependent ..." in: The Journal of biological chemistry, Vol. 284, Issue 44, pp. 30372-82, (2009) (PubMed).

  • Target
    ASK1 (MAP3K5) (Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5))
    Alternative Name
    MAP3K5 (MAP3K5 Products)
    Synonyms
    ASK1 antibody, MAPKKK5 antibody, MEKK5 antibody, mitogen-activated protein kinase kinase kinase 5 antibody, MUD21.11 antibody, MUD21_11 antibody, 7420452D20Rik antibody, ASK antibody, Mekk5 antibody, Ask1 antibody, RGD1306565 antibody, mitogen-activated protein kinase kinase kinase 5 antibody, MAP3K5 antibody, MAPKKK5 antibody, Map3k5 antibody, map3k5 antibody
    Background

    Description: Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells, MAPKKK5 does not activate MAPK/ERK.

    Aliases: ASK1, MEKK5, MAPKKK5

    Molecular Weight
    55 kDa
    Gene ID
    4217
    HGNC
    4217
    Pathways
    MAPK Signaling, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response
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