KPNA1 antibody (AA 1-538)

Catalog No. ABIN561614

Product Details anti-KPNA1 Antibody

Target: KPNA1 (Karyopherin alpha 1 (Importin alpha 5) (KPNA1))

Binding Specificity: AA 1-538

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This KPNA1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Mouse monoclonal antibody raised against a full length recombinant KPNA1.

Sequence: MTTPGKENFR LKSYKNKSLN PDEMRRRREE EGLQLRKQKR EEQLFKRRNV ATAEEETEEE VMSDGGFHEA QINNMEMAPG GVITSDMIEM IFSKSPEQQL SATQKFRKLL SKEPNPPIDE VISTPGVVAR FVEFLKRKEN CTLQFESAWV LTNIASGNSL QTRIVIQAGA VPIFIELLSS EFEDVQEQAV WALGNIAGDS TMCRDYVLDC NILPPLLQLF SKQNRLTMTR NAVWALSNLC RGKSPPPEFA KVSPCLNVLS WLLFVSDTDV LADACWALSY LSDGPNDKIQ AVIDAGVCRR LVELLMHNDY KVVSPALRAV GNIVTGDDIQ TQVILNCSAL QSLLHLLSSP KESIKKEACW TISNITAGNR AQIQTVIDAN IFPALISILQ TAEFRTRKEA AWAITNATSG GSAEQIKYLV ELGCIKPLCD LLTVMDSKIV QVALNGLENI LRLGEQEAKR NGTGINPYCA LIEEAYGLDK IEFLQSHENQ EIYQKAFDLI EHYFGTEDED SSIAPQVDLN QQQYIFQQCE APMEGFQL

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: KPNA1 (AAH02374.1, 1 a.a. ~ 538 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Clone: 2A4-1B5

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-KPNA1 antibody (ABIN561614)

Moriyama, Sangel, Yamaguchi, Obuse, Miyamoto, Oka, Yoneda: "Identification and characterization of a nuclear localization signal of TRIM28 that overlaps with the HP1 box." in: Biochemical and biophysical research communications, Vol. 462, Issue 3, pp. 201-7, (2015) (PubMed).

Moriyama, Nagai, Oka, Ikawa, Okabe, Yoneda: "Targeted disruption of one of the importin ? family members leads to female functional incompetence in delivery." in: The FEBS journal, Vol. 278, Issue 9, pp. 1561-72, (2011) (PubMed).

Nishimura, Zupunski, Troakes, Kathe, Fratta, Howell, Gallo, Hortobágyi, Shaw, Rogelj: "Nuclear import impairment causes cytoplasmic trans-activation response DNA-binding protein accumulation and is associated with frontotemporal lobar degeneration." in: Brain : a journal of neurology, Vol. 133, Issue Pt 6, pp. 1763-71, (2010) (PubMed).

Target Details for KPNA1

Target: KPNA1 (Karyopherin alpha 1 (Importin alpha 5) (KPNA1))

Alternative Name: KPNA1 (KPNA1 Products)

Synonyms: IPOA5 antibody, NPI-1 antibody, RCH2 antibody, SRP1 antibody, AW494490 antibody, NPI1 antibody, Rch2 antibody, mSRP1 antibody, si:ch211-161h7.7 antibody, karyopherin subunit alpha 1 antibody, importin alpha-1 subunit antibody, karyopherin (importin) alpha 1 antibody, karyopherin alpha 1 (importin alpha 5) antibody, KPNA1 antibody, Kpna1 antibody, EHI_124900 antibody, kpna1 antibody

Background: Full Gene Name: karyopherin alpha 1 (importin alpha 5)
Synonyms: IPOA5,NPI-1,RCH2,SRP1

Gene ID: 3836

Pathways: M Phase, Protein targeting to Nucleus