NR2F2 antibody (C-Term)

Catalog No. ABIN2781131

Product Details anti-NR2F2 Antibody

Target: NR2F2 (Nuclear Receptor Subfamily 2, Group F, Member 2 (NR2F2))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Dog, Cow, Rabbit, Zebrafish (Danio rerio), Guinea Pig, Sheep, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NR2F2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: EYSCLKAIVL FTSDACGLSD VAHVESLQEK SQCALEEYVR SQYPNQPTRF

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against NR2F2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human NR2F2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 414 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-NR2F2 antibody (ABIN2781131)

Cho, Yi, Tserentsoodol, Searle, Ferreira: "Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress." in: Disease models & mechanisms, Vol. 3, Issue 9-10, pp. 595-604, (2010) (PubMed).

Target Details for NR2F2

Target: NR2F2 (Nuclear Receptor Subfamily 2, Group F, Member 2 (NR2F2))

Alternative Name: NR2F2 (NR2F2 Products)

Synonyms: nr2f2 antibody, MGC52954 antibody, ARP1 antibody, COUPTFB antibody, COUPTFII antibody, NF-E3 antibody, NR2F1 antibody, SVP40 antibody, TFCOUP2 antibody, 2700033K02Rik antibody, 9430015G03Rik antibody, ARP-1 antibody, Aporp1 antibody, COUP-TF2 antibody, COUP-TFII antibody, EAR3 antibody, Tcfcoup2 antibody, Tfcoup2 antibody, fc94g08 antibody, svp40 antibody, svp[40] antibody, wu:fc94g08 antibody, nuclear receptor subfamily 2 group F member 2 L homeolog antibody, Nr2f2 protein antibody, nuclear receptor subfamily 2 group F member 2 antibody, nuclear receptor subfamily 2, group F, member 2 antibody, nr2f2.L antibody, nr2f2 antibody, NR2F2 antibody, Nr2f2 antibody

Background: NR2F2, an orphan member of the nuclear hormone receptor superfamily, acts as a transcriptional repressor by antagonizing the functions of other nuclear hormone receptors and by actively silencing transcription. However, in certain contexts, NR2F2 stimulates transcription directly. NR2F2, MyoD and p300 interact in a competitive manner, and that increasing amounts of NR2F2 have the ability to reduce the interaction between myoD and p300 invitro. NR2F2 post-transcriptionally regulates myoD activity/function, and that crosstalk between orphan nuclear receptors and the myogenic bHLH proteins has functional consequences for differentiation.
Alias Symbols: ARP1, NF-E3, NR2F1, SVP40, COUPTFB, TFCOUP2, COUPTFII
Protein Interaction Partner: NSD1, BCL11A, NR2F2, BIK, SETD7, FAM46A, HIPK3, UBC, TFAP4, Cebpb, SMARCAD1, NR2F6, POU5F1, NR3C1, PHB2, TRIP4, PIAS1, BCL11B, TRIM24, EP300, SQSTM1, HDAC1, NCOR2, MYOD1, LCK,
Protein Size: 414

Molecular Weight: 46 kDa

Gene ID: 7026

NCBI Accession: NM_021005, NP_066285

UniProt: P24468

Pathways: Steroid Hormone Mediated Signaling Pathway