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STAT3 antibody (C-Term)

STAT3 Reactivity: Human WB Host: Rabbit Polyclonal RB41075 unconjugated
Catalog No. ABIN1881850
  • Target See all STAT3 Antibodies
    STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))
    Binding Specificity
    • 90
    • 54
    • 26
    • 7
    • 7
    • 7
    • 7
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 673-699, C-Term
    Reactivity
    • 276
    • 142
    • 136
    • 38
    • 25
    • 25
    • 22
    • 17
    • 17
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    Human
    Host
    • 227
    • 58
    • 4
    • 2
    • 1
    • 1
    Rabbit
    Clonality
    • 195
    • 96
    Polyclonal
    Conjugate
    • 163
    • 23
    • 17
    • 10
    • 9
    • 9
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    This STAT3 antibody is un-conjugated
    Application
    • 217
    • 110
    • 75
    • 57
    • 51
    • 42
    • 41
    • 41
    • 27
    • 24
    • 15
    • 8
    • 6
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Predicted Reactivity
    B, M, Pig, Rat
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This STAT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 673-699 amino acids from the C-terminal region of human STAT3.
    Clone
    RB41075
    Isotype
    Ig Fraction
    Top Product
    Discover our top product STAT3 Primary Antibody
  • Application Notes
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Yin, Du, Cao, Liu, Xu, Xiang: "Reg3g Promotes Pancreatic Carcinogenesis in a Murine Model of Chronic Pancreatitis." in: Digestive diseases and sciences, (2015) (PubMed).

    Li, Cheung, Evans, Shaw: "Modulation of gene expression and tumor cell growth by redox modification of STAT3." in: Cancer research, Vol. 70, Issue 20, pp. 8222-32, (2010) (PubMed).

    Takaishi, Komohara, Tashiro, Ohtake, Nakagawa, Katabuchi, Takeya: "Involvement of M2-polarized macrophages in the ascites from advanced epithelial ovarian carcinoma in tumor progression via Stat3 activation." in: Cancer science, Vol. 101, Issue 10, pp. 2128-36, (2010) (PubMed).

    Li, Zou, Li: "Up-regulation of signal transducer and activator of transcription-3 is associated with aggravation of ulcerative colitis." in: The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland, Vol. 8, Issue 5, pp. 262-6, (2010) (PubMed).

    Schimke, Sawalle-Belohradsky, Roesler, Wollenberg, Rack, Borte, Rieber, Cremer, Maass, Dopfer, Reichenbach, Wahn, Hoenig, Jansson, Roesen-Wolff, Schaub, Seger, Hill, Ochs, Torgerson et al.: "Diagnostic approach to the hyper-IgE syndromes: immunologic and clinical key findings to differentiate hyper-IgE syndromes from atopic dermatitis...." in: The Journal of allergy and clinical immunology, Vol. 126, Issue 3, pp. 611-7.e1, (2010) (PubMed).

    Iliopoulos, Jaeger, Hirsch, Bulyk, Struhl: "STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer." in: Molecular cell, Vol. 39, Issue 4, pp. 493-506, (2010) (PubMed).

  • Target
    STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))
    Alternative Name
    STAT3 (STAT3 Products)
    Synonyms
    1110034C02Rik antibody, AW109958 antibody, Aprf antibody, APRF antibody, HIES antibody, Xstat3 antibody, aprf antibody, hies antibody, stat3 antibody, wu:fc15d02 antibody, wu:fl59g06 antibody, z-Stat3 antibody, signal transducer and activator of transcription 3 antibody, signal transduction and activation of transcription 3 antibody, signal transducer and activator of transcription 3, gene 1 L homeolog antibody, signal transducer and activator of transcription 3 (acute-phase response factor) antibody, STAT3 antibody, stat3 antibody, Stat3 antibody, stat3.1.L antibody
    Background
    The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
    Molecular Weight
    88068
    NCBI Accession
    NP_003141, NP_644805, NP_998827
    UniProt
    P40763
    Pathways
    JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Neurotrophin Signaling Pathway, Dopaminergic Neurogenesis, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Stem Cell Maintenance, Hepatitis C, Protein targeting to Nucleus, Feeding Behaviour, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor
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