Coagulation Factor II (thrombin) Receptor-Like 1 (F2RL1) Peptide

Catalog No. ABIN399760

Product Details

Target: F2RL1 (Coagulation Factor II (thrombin) Receptor-Like 1 (F2RL1))

Purity: > 95 %

Application Details

Restrictions: For Research Use only

Handling

Storage: -20 °C

References

Post, Nawijn, Jonker, Kliphuis, van den Berge, van Oosterhout, Heijink: "House dust mite-induced calcium signaling instigates epithelial barrier dysfunction and CCL20 production." in: Allergy, Vol. 68, Issue 9, pp. 1117-25, (2013) (PubMed).

Akiyama, Carstens, Carstens: "Enhanced responses of lumbar superficial dorsal horn neurons to intradermal PAR-2 agonist but not histamine in a mouse hindpaw dry skin itch model." in: Journal of neurophysiology, Vol. 105, Issue 6, pp. 2811-7, (2011) (PubMed).

Denadai-Souza, Cenac, Casatti, Câmara, Yshii, Costa, Vergnolle, Muscará: "PAR(2) and temporomandibular joint inflammation in the rat." in: Journal of dental research, Vol. 89, Issue 10, pp. 1123-8, (2010) (PubMed).

Akiyama, Carstens, Carstens: "Excitation of mouse superficial dorsal horn neurons by histamine and/or PAR-2 agonist: potential role in itch." in: Journal of neurophysiology, Vol. 102, Issue 4, pp. 2176-83, (2009) (PubMed).

Target Details

Target: F2RL1 (Coagulation Factor II (thrombin) Receptor-Like 1 (F2RL1))

Synonyms: par2 Peptide, GPR11 Peptide, PAR2 Peptide, Gpcr11 Peptide, PAR-2 Peptide, Par2 Peptide, Par-2 Peptide, Proteinase-activated receptor 2 Peptide, F2R like trypsin receptor 1 Peptide, coagulation factor II (thrombin) receptor-like 1 Peptide, par2 Peptide, F2RL1 Peptide, F2rl1 Peptide

Background: A PAR-2 activating peptide (PAR-2-AP), the putative N-terminal activating peptide sequence of the rat PAR2 receptor (SLIGRL) is identical with the one previously cloned from murine tissue. We concluded that, like the thrombin receptor, the PAR2 receptor may play a pathophysiologic role in the regulation of vascular and gastric smooth muscle contractility.