KLF1 antibody (AA 208-362)

Catalog No. ABIN1724828

Product Details anti-KLF1 Antibody

Target: KLF1 (Kruppel-Like Factor 1 (erythroid) (KLF1))

Binding Specificity: AA 208-362

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This KLF1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Purification: purified

Immunogen: Purified recombinant fragment of human KLF1 (AA: 208-362) expressed in E. coli.

Clone: 1B6A3

Isotype: IgG1

Application Details

Application Notes: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, FCM: 1:200 - 1:400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

References for anti-KLF1 antibody (ABIN1724828)

Alhashem, Vinjamur, Basu, Klingmüller, Gaensler, Lloyd: "Transcription factors KLF1 and KLF2 positively regulate embryonic and fetal beta-globin genes through direct promoter binding." in: The Journal of biological chemistry, Vol. 286, Issue 28, pp. 24819-27, (2011) (PubMed).

Zhou, Liu, Sun, Pawlik, Townes: "KLF1 regulates BCL11A expression and gamma- to beta-globin gene switching." in: Nature genetics, Vol. 42, Issue 9, pp. 742-4, (2010) (PubMed).

Target Details for KLF1

Target: KLF1 (Kruppel-Like Factor 1 (erythroid) (KLF1))

Alternative Name: KLF1 (KLF1 Products)

Synonyms: KLF1 antibody, EKLF antibody, HBFQTL6 antibody, INLU antibody, Eklf antibody, Nan antibody, Kruppel-like factor 1 (erythroid) antibody, Kruppel like factor 1 antibody, KLF-4 antibody, KLF1 antibody, Klf1 antibody

Background:

Description: This gene encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the dominant In(Lu) blood phenotype. , ,

Aliases: EKLF, INLU, HBFQTL6

Molecular Weight: 38.2 kDa

Gene ID: 10661

HGNC: 10661