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SYVN1 antibody (N-Term)

SYVN1 Reactivity: Human WB Host: Rabbit Polyclonal RB5086 unconjugated
Catalog No. ABIN1882139
  • Target See all SYVN1 Antibodies
    SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))
    Binding Specificity
    • 16
    • 10
    • 8
    • 6
    • 5
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 58-88, N-Term
    Reactivity
    • 58
    • 36
    • 10
    • 7
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 54
    • 2
    • 2
    Rabbit
    Clonality
    • 56
    • 2
    Polyclonal
    Conjugate
    • 29
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SYVN1 antibody is un-conjugated
    Application
    • 49
    • 27
    • 18
    • 15
    • 13
    • 13
    • 7
    • 5
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB)
    Predicted Reactivity
    M, X
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This SYVN1 (HRD1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-88 amino acids from the N-terminal region of human SYVN1 (HRD1).
    Clone
    RB5086
    Isotype
    Ig Fraction
    Top Product
    Discover our top product SYVN1 Primary Antibody
  • Application Notes
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Smith, Granell, Salcedo-Sicilia, Baldini, Egea, Teckman, Baldini: "Activating transcription factor 6 limits intracellular accumulation of mutant ?(1)-antitrypsin Z and mitochondrial damage in hepatoma cells." in: The Journal of biological chemistry, Vol. 286, Issue 48, pp. 41563-77, (2011) (PubMed).

    Klemm, Spooner, Ploegh: "Dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and endoplasmic reticulum (ER) protein quality control." in: The Journal of biological chemistry, Vol. 286, Issue 43, pp. 37602-14, (2011) (PubMed).

    Huang, Marvin, Tatsis, Eisenlohr: "Cutting Edge: Selective role of ubiquitin in MHC class I antigen presentation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 186, Issue 4, pp. 1904-8, (2011) (PubMed).

    Kikkert, Doolman, Dai, Avner, Hassink, van Voorden, Thanedar, Roitelman, Chau, Wiertz: "Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum." in: The Journal of biological chemistry, Vol. 279, Issue 5, pp. 3525-34, (2004) (PubMed).

    Amano, Yamasaki, Yagishita, Tsuchimochi, Shin, Kawahara, Aratani, Fujita, Zhang, Ikeda, Fujii, Miura, Komiya, Nishioka, Maruyama, Fukamizu, Nakajima: "Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy." in: Genes & development, Vol. 17, Issue 19, pp. 2436-49, (2003) (PubMed).

    Nadav, Shmueli, Barr, Gonen, Ciechanover, Reiss: "A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1." in: Biochemical and biophysical research communications, Vol. 303, Issue 1, pp. 91-7, (2003) (PubMed).

  • Target
    SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))
    Alternative Name
    SYVN1 (HRD1) (SYVN1 Products)
    Synonyms
    DER3 antibody, HRD1 antibody, hrd1 antibody, 1200010C09Rik antibody, AW211966 antibody, C85322 antibody, D530017H19Rik antibody, Hrd1 antibody, RGD1310488 antibody, syvn1 antibody, syvn1-a antibody, syvn1-b antibody, wu:fk91f10 antibody, zgc:55735 antibody, zgc:77108 antibody, synoviolin 1 antibody, synovial apoptosis inhibitor 1, synoviolin antibody, synoviolin 1 S homeolog antibody, SYVN1 antibody, syvn1 antibody, Syvn1 antibody, syvn1.S antibody
    Background
    HRD1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of HRD1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. HRD1 is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney and skeletal muscle. Synoviolin/Hrd1 (expressed in rheumatoid synovium) is reported to be a novel causative factor for arthropathy by triggering synovial cell outgrowth through its antiapoptotic effects. HRD1 contains one ring-type zinc finger.
    Molecular Weight
    67685
    NCBI Accession
    NP_115807, NP_757385
    UniProt
    Q86TM6
    Pathways
    ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling
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