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DGCR8 antibody (N-Term)

DGCR8 Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Guinea Pig, Zebrafish (Danio rerio) WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2776557
  • Target See all DGCR8 Antibodies
    DGCR8 (DiGeorge Syndrome Critical Region Gene 8 (DGCR8))
    Binding Specificity
    • 8
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Guinea Pig, Zebrafish (Danio rerio)
    Host
    • 37
    • 6
    • 1
    Rabbit
    Clonality
    • 28
    • 16
    Polyclonal
    Conjugate
    • 32
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This DGCR8 antibody is un-conjugated
    Application
    • 33
    • 18
    • 10
    • 10
    • 8
    • 5
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    DKKDEENELD QEKRVEYAVL DELEDFTDNL ELDEEGAGGF TAKAIVQRDR
    Predicted Reactivity
    Cow: 85%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 77%
    Characteristics
    This is a rabbit polyclonal antibody against DGCR8. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human DGCR8
    Top Product
    Discover our top product DGCR8 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 773 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Belair, Paikari, Moltzahn, Shenoy, Yau, DallEra, Simko, Benz, Blelloch: "DGCR8 is essential for tumor progression following PTEN loss in the prostate." in: EMBO reports, Vol. 16, Issue 9, pp. 1219-32, (2015) (PubMed).

    Van Duyne, Guendel, Klase, Narayanan, Coley, Jaworski, Roman, Popratiloff, Mahieux, Kehn-Hall, Kashanchi: "Localization and sub-cellular shuttling of HTLV-1 tax with the miRNA machinery." in: PLoS ONE, Vol. 7, Issue 7, pp. e40662, (2012) (PubMed).

    Kye, Neveu, Lee, Zhou, Steen, Sahin, Kosik, Silva: "NMDA mediated contextual conditioning changes miRNA expression." in: PLoS ONE, Vol. 6, Issue 9, pp. e24682, (2011) (PubMed).

  • Target
    DGCR8 (DiGeorge Syndrome Critical Region Gene 8 (DGCR8))
    Alternative Name
    DGCR8 (DGCR8 Products)
    Synonyms
    MGC78846 antibody, DGCR8 antibody, gy1 antibody, dgcrk6 antibody, C22orf12 antibody, DGCRK6 antibody, Gy1 antibody, pasha antibody, D16H22S1742E antibody, D16H22S788E antibody, D16Wis2 antibody, N41 antibody, Vo59c07 antibody, si:ch211-106a19.4 antibody, wu:fc23f08 antibody, wu:fc38f06 antibody, DGCR8 microprocessor complex subunit L homeolog antibody, DiGeorge syndrome critical region gene 8 antibody, DGCR8 microprocessor complex subunit antibody, DGCR8, microprocessor complex subunit antibody, microRNA 3618 antibody, dgcr8.L antibody, DGCR8 antibody, dgcr8 antibody, Dgcr8 antibody, MIR3618 antibody
    Background
    DGCR8 contains 2 DRBM (double-stranded RNA-binding) domains and 1 WW domain. It may play a part in the etiology of the velocardiofacial/DiGeorge syndrome (VCFS/DGS), a developmental disorder characterized by structural and functional palate anomalies, conotruncal cardiac malformations, immunodeficiency, hypocalcemia, and typical facial anomalies.
    Alias Symbols: C22orf12, DGCRK6, Gy1, pasha
    Protein Interaction Partner: MEOX2, PYCRL, DROSHA, RAE1, MAPK1, PRMT1, ERH, CDKN2A, BMI1, SRPK2, SRPK1, CDT1, NAT10, PLEK2, RPRD2, MAPRE2, PRPF4, FLII, APP, CUL3, DDX17, HNRNPR, NCL, ILF3, HSPA8, HSPA5, HNRNPU, HNRNPH1, FUS, DHX9, DDX5,
    Protein Size: 773
    Molecular Weight
    85 kDa
    Gene ID
    54487
    NCBI Accession
    NM_022720, NP_073557
    UniProt
    Q8WYQ5
    Pathways
    Regulatory RNA Pathways
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