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FGD1 antibody (N-Term)

FGD1 Reactivity: Human, Cow, Pig, Rat WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2780596
  • Target See all FGD1 Antibodies
    FGD1 (FYVE, RhoGEF and PH Domain Containing 1 (FGD1))
    Binding Specificity
    • 3
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 7
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Cow, Pig, Rat
    Host
    • 7
    Rabbit
    Clonality
    • 7
    Polyclonal
    Conjugate
    • 7
    This FGD1 antibody is un-conjugated
    Application
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    HGHRAPGGAG PSEPEHPATN PPGAAPPACA DSDPGASEPG LLARRGSGSA
    Predicted Reactivity
    Cow: 86%, Human: 100%, Pig: 86%, Rat: 79%
    Characteristics
    This is a rabbit polyclonal antibody against FGD1. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human FGD1
    Top Product
    Discover our top product FGD1 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 961 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Zou, Greenblatt, Shim, Kant, Zhai, Lotinun, Brady, Hu, Gygi, Baron, Davis, Jones, Glimcher: "MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice." in: The Journal of clinical investigation, Vol. 121, Issue 11, pp. 4383-92, (2011) (PubMed).

  • Target
    FGD1 (FYVE, RhoGEF and PH Domain Containing 1 (FGD1))
    Alternative Name
    FGD1 (FGD1 Products)
    Synonyms
    AAS antibody, FGDY antibody, MRXS16 antibody, ZFYVE3 antibody, FYVE, RhoGEF and PH domain containing 1 antibody, FGD1 antibody, Fgd1 antibody, fgd1 antibody
    Background
    FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome.FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: AAS, FGDY, ZFYVE3, MRXS16
    Protein Interaction Partner: BTRC, UBC, ELAVL1, ELMO1, CTTN, CDC42, AOC1,
    Protein Size: 961
    Molecular Weight
    106 kDa
    Gene ID
    2245
    NCBI Accession
    NM_004463, NP_004454
    UniProt
    P98174
    Pathways
    Neurotrophin Signaling Pathway
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