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Pan SUMO antibody

Reactivity: Human, Rat IF, IHC (p), WB Host: Rabbit Polyclonal RB04602 unconjugated
Catalog No. ABIN388089
  • Target
    Pan SUMO
    Reactivity
    Human, Rat
    Host
    Rabbit
    Clonality
    Polyclonal
    Application
    Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    "This Pan SUMO antibody recognizes SUMO2 and SUMO3. This antibody is generated from rabbits immunized with a recombinant protein encoding full length human SUMO3."
    Clone
    RB04602
    Isotype
    Ig Fraction
  • Application Notes
    IF: 1:10~50. WB: 1:1000. IHC-P: 1:100. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Dunphy, Luo, McBride: "Ehrlichia chaffeensis exploits host SUMOylation pathways to mediate effector-host interactions and promote intracellular survival." in: Infection and immunity, Vol. 82, Issue 10, pp. 4154-68, (2014) (PubMed).

    Sun, Hunter: "Poly-small ubiquitin-like modifier (PolySUMO)-binding proteins identified through a string search." in: The Journal of biological chemistry, Vol. 287, Issue 50, pp. 42071-83, (2012) (PubMed).

    Lutz, Wolters-Eisfeld, Joshi, Djogo, Jakovcevski, Schachner, Kleene: "Generation and nuclear translocation of sumoylated transmembrane fragment of cell adhesion molecule L1." in: The Journal of biological chemistry, Vol. 287, Issue 21, pp. 17161-75, (2012) (PubMed).

  • Target
    Pan SUMO
    Background
    Covalent modification of target lysines by SUMO (small ubiquitin-like modifier) modulates processes such as protein localization, transcription, nuclear transport, mitosis, DNA replication and repair, signal transduction, and viral reproduction. SUMO does not seem to be involved in protein degradation and may in fact function as an antagonist of ubiquitin in the degradation process. The SUMO family consists of SUMO1 and closely related homologs SUMO2, SUMO3, and SUMO4. Sumoylation has been shown to regulate a wide range of proteins, including MDM2, PIAS, PML, RanGAP1, RanBP2, p53, p73, HIPK2, TEL, c-Jun, Fas, Daxx, TNFRI, Topo-I, Topo-II, PARK2, WRN, Sp100, IkB-alpha, Androgen receptor (AR), GLUT1/4, CaMK, DNMT3B, TDG, HIF1A, CHD3, EXOSC9, RAD51, and viral targets such as CMV-IE1/2, EBV-BZLF1, and HPV/BPV-E1.
    Molecular Weight
    11637
    Gene ID
    6612
    NCBI Accession
    NP_008867
    UniProt
    P55854
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