DLL1 antibody (N-Term)

Catalog No. ABIN2782684

Product Details anti-DLL1 Antibody

Target: DLL1 (delta-Like 1 (DLL1))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DLL1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: GSRCALALAV LSALLCQVWS SGVFELKLQE FVNKKGLLGN RNCCRGGAGP

Predicted Reactivity: Cow: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against DLL1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human DLL1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 723 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-DLL1 antibody (ABIN2782684)

Caliceti, Aquila, Pannella, Morelli, Fortini, Pinton, Bonora, Hrelia, Pannuti, Miele, Rizzo, Ferrari: "17?-estradiol enhances signalling mediated by VEGF-A-delta-like ligand 4-notch1 axis in human endothelial cells." in: PLoS ONE, Vol. 8, Issue 8, pp. e71440, (2013) (PubMed).

Suprynowicz, Upadhyay, Krawczyk, Kramer, Hebert, Liu, Yuan, Cheluvaraju, Clapp, Boucher, Kamonjoh, Randell, Schlegel: "Conditionally reprogrammed cells represent a stem-like state of adult epithelial cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 49, pp. 20035-40, (2012) (PubMed).

Target Details for DLL1

Target: DLL1 (delta-Like 1 (DLL1))

Alternative Name: DLL1 (DLL1 Products)

Synonyms: X-delta-1 antibody, XDelta1 antibody, Xdelta-1 antibody, delta antibody, delta-1 antibody, delta1 antibody, x-delta antibody, DELTA1 antibody, DL1 antibody, Delta antibody, DLK antibody, DLK-1 antibody, Delta1 antibody, FA1 antibody, PREF1 antibody, Pref-1 antibody, ZOG antibody, pG2 antibody, DLL1 antibody, AW742678 antibody, DlkI antibody, Ly107 antibody, Peg9 antibody, SCP1 antibody, pref-1 antibody, delta-like 1 antibody, delta like canonical Notch ligand 1 antibody, delta like non-canonical Notch ligand 1 antibody, delta-like 1 L homeolog antibody, delta-like 1 (Drosophila) antibody, delta-like 1 homolog (Drosophila) antibody, dll1 antibody, DLL1 antibody, DLK1 antibody, Dll1 antibody, dll1.L antibody, Dlk1 antibody

Background: DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication.DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: DELTA1, Delta, DL1
Protein Interaction Partner: EPN1, UBC, MIB1, MAGI2, CNKSR3, POFUT1, DLL1, MFNG, ADAM10, NOTCH3, NOTCH2, NOTCH1, NOV, PSEN1, MAGI1,
Protein Size: 723

Molecular Weight: 78 kDa

Gene ID: 28514

NCBI Accession: NM_005618, NP_005609

UniProt: O00548

Pathways: Notch Signaling, Stem Cell Maintenance