CCDC90A antibody (Middle Region)

Catalog No. ABIN2782009

Product Details anti-CCDC90A Antibody

Target: CCDC90A (MCUR1) (Mitochondrial Calcium Uniporter Regulator 1 (MCUR1))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCDC90A antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: ELHQLKQQVM DEVIKVRTDT KLDFNLEKSR VKELYSLNEK KLLELRTEIV

Predicted Reactivity: Cow: 79%, Dog: 86%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against CCDC90A. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CCDC90A

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 359 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-CCDC90A antibody (ABIN2782009)

Shanmughapriya, Rajan, Hoffman, Zhang, Guo, Kolesar, Hines, Ragheb, Jog, Caricchio, Baba, Zhou, Kaufman, Cheung, Kurosaki, Gill, Madesh: "Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU." in: Science signaling, Vol. 8, Issue 366, pp. ra23, (2015) (PubMed).

Mallilankaraman, Cárdenas, Doonan, Chandramoorthy, Irrinki, Golenár, Csordás, Madireddi, Yang, Müller, Miller, Kolesar, Molgó, Kaufman, Hajnóczky, Foskett, Madesh: "MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism." in: Nature cell biology, Vol. 14, Issue 12, pp. 1336-43, (2012) (PubMed).

Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: "Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France." in: Diagnostic microbiology and infectious disease, Vol. 55, Issue 1, pp. 55-8, (2006) (PubMed).

Kimura, Wakamatsu, Suzuki, Ota, Nishikawa, Yamashita, Yamamoto, Sekine, Tsuritani, Wakaguri, Ishii, Sugiyama, Saito, Isono, Irie, Kushida, Yoneyama, Otsuka, Kanda, Yokoi, Kondo, Wagatsuma, Murakawa et al.: "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. ..." in: Genome research, Vol. 16, Issue 1, pp. 55-65, (2006) (PubMed).

Target Details for CCDC90A

Target: CCDC90A (MCUR1) (Mitochondrial Calcium Uniporter Regulator 1 (MCUR1))

Alternative Name: CCDC90A (MCUR1 Products)

Synonyms: C6orf79 antibody, CCDC90A antibody, 6230416A05Rik antibody, AU015498 antibody, AV136929 antibody, AW554392 antibody, C88263 antibody, Ccdc90a antibody, RGD1307673 antibody, mitochondrial calcium uniporter regulator 1 antibody, mitochondrial calcium uniporter regulator 1 L homeolog antibody, MCUR1 antibody, Mcur1 antibody, mcur1.L antibody

Background: Essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism.
Alias Symbols: C6orf79, FLJ20958, CCDC90A
Protein Size: 359

Molecular Weight: 40 kDa

Gene ID: 63933

NCBI Accession: NM_001031713, NP_001026883

UniProt: Q96AQ8