GLI1 antibody (AA 601-700)

Catalog No. ABIN673374

Product Details anti-GLI1 Antibody

Target: GLI1 (Zinc Finger Protein GLI1 (GLI1))

Binding Specificity: AA 601-700

Reactivity: Human, Mouse, Rat, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GLI1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Mouse, Pig, Rat

Predicted Reactivity: Dog,Cow,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GLI1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-GLI1 antibody (ABIN673374)

Fan, Li, Liu, Cong, Zhao, Cao, Zheng: "Doxorubicin combined with low intensity ultrasound suppresses the growth of oral squamous cell carcinoma in culture and in xenografts." in: Journal of experimental & clinical cancer research : CR, Vol. 36, Issue 1, pp. 163, (2018) (PubMed).

Yang, Wu, Feng, Huang, Liu, Liu, Chen: "Vitamin C plus hydrogel facilitates bone marrow stromal cell-mediated endometrium regeneration in rats." in: Stem cell research & therapy, Vol. 8, Issue 1, pp. 267, (2017) (PubMed).

Long, Wang, Zheng, Lai, Xu, Hu, Lin, Zhang, Dong, Long, Tong, Liu: "Targeting GLI1 Suppresses Cell Growth and Enhances Chemosensitivity in CD34+ Enriched Acute Myeloid Leukemia Progenitor Cells." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 38, Issue 4, pp. 1288-302, (2016) (PubMed).

Ma, Liu, Zeng, Zhou, Guo, Xie, Yang, Zheng, Xu, Wang, Chang, He, Li: "Silibinin induces apoptosis through inhibition of the mTOR-GLI1-BCL2 pathway in renal cell carcinoma." in: Oncology reports, Vol. 34, Issue 5, pp. 2461-8, (2015) (PubMed).

Fan, Wang, Zhao, Liu, Chen, Sun, Zheng: "Sonic hedgehog signaling may promote invasion and metastasis of oral squamous cell carcinoma by activating MMP-9 and E-cadherin expression." in: Medical oncology (Northwood, London, England), Vol. 31, Issue 7, pp. 41, (2014) (PubMed).

Zhang, Zhu, Zhou, Gao, Yuan, Han: "Serotonin receptor 2C and insulin secretion." in: PLoS ONE, Vol. 8, Issue 1, pp. e54250, (2013) (PubMed).

Yue, Zhong, Pei, Xiao, Zhang, Jiang, Zhang, Chen, Yang, Dang, Chang: "Aberrant activation of hedgehog pathway in nasopharyngeal carcinoma." in: Clinical and experimental medicine, Vol. 13, Issue 4, pp. 315-22, (2013) (PubMed).

Du, Feng, Wang, Piao, Cui, Chen, Lei, Sun, Liu, Wang, Li, Yang, Sun, Zhao, Jiang, Li, Jiang: "Curcumin suppresses malignant glioma cells growth and induces apoptosis by inhibition of SHH/GLI1 signaling pathway in vitro and vivo." in: CNS neuroscience & therapeutics, Vol. 19, Issue 12, pp. 926-36, (2013) (PubMed).

Target Details for GLI1

Target: GLI1 (Zinc Finger Protein GLI1 (GLI1))

Alternative Name: GLI1 (GLI1 Products)

Synonyms: GLI antibody, Gli antibody, Gli-1 antibody, gli1.1 antibody, AV235269 antibody, Zfp-5 antibody, Zfp5 antibody, GLI family zinc finger 1 antibody, GLI family zinc finger 1 S homeolog antibody, GLI-Kruppel family member GLI1 antibody, GLI1 antibody, Gli1 antibody, gli1.S antibody, gli1 antibody

Background:

Synonyms: GLI, Zinc finger protein GLI1, Glioma-associated oncogene, Oncogene GLI, GLI1

Background: Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation.

Gene ID: 2735

UniProt: P08151

Pathways: Hedgehog Signaling, Dopaminergic Neurogenesis