DYRK3 antibody (N-Term)

Catalog No. ABIN2779364

Product Details anti-DYRK3 Antibody

Target: DYRK3 (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 3 (DYRK3))

Binding Specificity: N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DYRK3 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Sequence: GDHTQHFLDG GEMKVEQLFQ EFGNRKSNTI QSDGISDSEK CSPTVSQGKS

Predicted Reactivity: Human: 100%, Mouse: 86%

Characteristics: This is a rabbit polyclonal antibody against DYRK3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human DYRK3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 588 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-DYRK3 antibody (ABIN2779364)

Wippich, Bodenmiller, Trajkovska, Wanka, Aebersold, Pelkmans: "Dual specificity kinase DYRK3 couples stress granule condensation/dissolution to mTORC1 signaling." in: Cell, Vol. 152, Issue 4, pp. 791-805, (2013) (PubMed).

Target Details for DYRK3

Target: DYRK3 (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 3 (DYRK3))

Alternative Name: DYRK3 (DYRK3 Products)

Synonyms: DYRK5 antibody, RED antibody, REDK antibody, hYAK3-2 antibody, BC006704 antibody, DYRK3 antibody, MGC89944 antibody, dual specificity tyrosine phosphorylation regulated kinase 3 antibody, dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 antibody, dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3 antibody, dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3 L homeolog antibody, DYRK3 antibody, Dyrk3 antibody, dyrk3 antibody, dyrk3.L antibody

Background: This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified.
Alias Symbols: DYRK5, RED, REDK, hYAK3-2
Protein Interaction Partner: DYRK3, SORL1, FBXO25, PRNP, NEDD4L,
Protein Size: 588

Molecular Weight: 66 kDa

Gene ID: 8444

NCBI Accession: NM_003582, NP_003573

UniProt: O43781

Pathways: Negative Regulation of Hormone Secretion, Regulation of Lipid Metabolism by PPARalpha