N-Formyl-Met-Leu-Phe Peptide

Catalog No. ABIN399635

Product Details

Target: N-Formyl-Met-Leu-Phe

Purification: The antibody is affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide is removed by chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site.

Purity: > 95 %

Application Details

Restrictions: For Research Use only

Handling

Storage: -20 °C

References

van den Broek, Kroeze, Waaijman, Breetveld, Sampat-Sardjoepersad, Niessen, Middelkoop, Scheper, Gibbs: "Differential response of human adipose tissue-derived mesenchymal stem cells, dermal fibroblasts, and keratinocytes to burn wound exudates: potential role of skin-specific chemokine CCL27." in: Tissue engineering. Part A, Vol. 20, Issue 1-2, pp. 197-209, (2014) (PubMed).

Target Details

Target: N-Formyl-Met-Leu-Phe

Target Type: Peptide

Background: N-formyl-methionyl-leucyl-phenylalanine (fMLP), the chemotactic bacterial peptide, was able to specifically attenuate Ca2+ mobilization in human phagocytes induced by SAA, but only at very high concentrations. The bacterial peptide N-formyl-methionyl-leucyl-phenylalanine (fMLF) is one of the first identified and highly potent leukocyte chemoattractants. fMLF interacts with at least two human cell receptors formyl peptide receptor (FPR) and its variant formyl peptide receptor-like 1 (FPRL1), both are members of the seven transmembrane domain, G protein-coupled receptor (GPCR) family.

CAS-No: 59880-97-6